Butenafine
(Redirected from Mentax-tc)
What is Butenafine?[edit | edit source]
- Butenafine (Lotrimin Ultra, Mentax, and Butop (India)) is a synthetic antifungal agent used for the topical treatment of tinea (pityriasis) versicolor due to Malassezia furfur, as well as athlete's foot (Tinea pedis), ringworm (Tinea corporis) and jock itch (Tinea cruris) due to Epidermophyton floccosum, Trichophyton mentagrophytes, Trichophyton rubrum, and Trichophyton tonsurans.
What are the uses of this medicine?[edit | edit source]
- Butenafine (Lotrimin Ultra, Mentax, and Butop (India)) used for the topical treatment of tinea (pityriasis) versicolor due to Malassezia furfur, as well as athlete's foot (Tinea pedis), ringworm (Tinea corporis) and jock itch (Tinea cruris) due to Epidermophyton floccosum, Trichophyton mentagrophytes, Trichophyton rubrum, and Trichophyton tonsurans.
- It also displays superior activity against Candida albicans than terbinafine and naftifine.
- Butenafine demonstrates low minimum inhibitory concentrations against Cryptococcus and Aspergillus.
How does this medicine work?[edit | edit source]
- Butenafine HCl is a benzylamine derivative with a mode of action similar to that of the allylamine class of antifungal drugs. Butenafine HCl is hypothesized to act by inhibiting the epoxidation of squalene, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes.
- The benzylamine derivatives, like the allylamines, act at an earlier step in the ergosterol biosynthesis pathway than the azole class of antifungal drugs.
- Depending on the concentration of the drug and the fungal species tested, butenafine HCl may be fungicidal or fungistatic in vitro.
Butenafine HCl has been shown to be active against most strains of the following microorganisms:
- Epidermophyton floccosum
- Trichophyton rubrum
- Malassezia furfur
- Trichophyton tonsurans
- Trichophyton mentagrophytes
Who Should Not Use this medicine ?[edit | edit source]
This medicine cannot be used in patients with:
- suspected sensitivity to butenafine.
What drug interactions can this medicine cause?[edit | edit source]
- Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
Is this medicine FDA approved?[edit | edit source]
- Yes, it is FDA approved.
How should this medicine be used?[edit | edit source]
Recommended dosage: For 1% cream: For adults and children 12 years and older:
- wash the affected skin with soap and water and dry completely before applying
- apply once a day to affected skin for 2 weeks or as directed by a doctor
- wash hands after each use
- children under 12 years: ask a doctor
Administration:
- Wash the affected skin with soap and water and dry completely before applying.
- apply once a day to affected skin for 2 weeks or as directed by a doctor.
- wash hands after each use.
What are the dosage forms and brand names of this medicine?[edit | edit source]
This medicine is available in fallowing doasage form:
- As a 1% topical cream.
This medicine is available in fallowing brand namesː
- Lotrimin Ultra, Mentax, and Butop (India)
What side effects can this medication cause?[edit | edit source]
The most common side effects of this medicine include:
- burning/stinging
- worsening of the condition
- itching at the site of application
- contact dermatitis
- erythema, irritation, and itching
What special precautions should I follow?[edit | edit source]
- Butenafine hydrochloride cream is not for ophthalmic, oral, or intravaginal use.
- Butenafine hydrochloride cream is for external use only. If irritation or sensitivity develops with the use of Mentax® Cream, 1%, treatment should be discontinued and appropriate therapy instituted.
- Patients who are known to be sensitive to allylamine antifungals should use butenafine HCl Cream, 1%, with caution since cross-reactivity may occur.
- Use butenafine HCl Cream, 1% as directed by the physician, and avoid contact with the eyes, nose, mouth, and other mucous membranes.
- The hands should be washed after applying the medication to the affected area(s).
- Dry the affected area(s) thoroughly before application, if you wish to apply butenafine HCl Cream, 1% after bathing.
- Use the medication for the full treatment time recommended by the physician, even though symptoms may have improved. Notify the physician if there is no improvement after the end of the prescribed treatment period, or sooner, if the condition worsens.
- Inform the physician if the area of application shows signs of increased irritation, redness, itching, burning, blistering, swelling, or oozing.
- Avoid the use of occlusive dressings unless otherwise directed by the physician.
- Do not use this medication for any disorder other than that for which it was prescribed.
What to do in case of emergency/overdose?[edit | edit source]
Symptoms of overdosage may include:
- Overdosage of butenafine HCl in humans has not been reported to date.
Management of overdosage:
- In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.
- Overdose related information is also available online at poisonhelp.org/help.
- In the event that the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services. In the United States, call 911.
Can this medicine be used in pregnancy?[edit | edit source]
- There are, however, no adequate and well-controlled studies that have been conducted with topically applied butenafine in pregnant women.
- Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
Can this medicine be used in children?[edit | edit source]
- Safety and efficacy in pediatric patients below the age of 12 years have not been studied.
What are the active and inactive ingredients in this medicine?[edit | edit source]
Active ingredient:
- BUTENAFINE HYDROCHLORIDE
Inactive ingredients:
- WATER
- PROPYLENE GLYCOL
- GLYCERIN
- CETYL ALCOHOL
- GLYCERYL MONOSTEARATE
- PETROLATUM
- STEARIC ACID
- BENZYL ALCOHOL
- DIETHANOLAMINE
- SODIUM BENZOATE
Who manufactures and distributes this medicine?[edit | edit source]
- Mylan Pharmaceuticals Inc.
- Morgantown, WV U.S.A.
What should I know about storage and disposal of this medication?[edit | edit source]
- STORE BETWEEN 5° and 30°C (41° and 86°F).
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