Negative-sense
Negative-sense single-stranded RNA virus (-ssRNA virus) is a type of virus that uses negative sense, single-stranded RNA as its genetic material. These viruses must first be converted to positive-sense RNA by an RNA-dependent RNA polymerase before they can be translated into protein for viral replication.
Replication[edit | edit source]
The replication of -ssRNA viruses is a complex process that involves the synthesis of a positive-sense RNA (mRNA) from the negative-sense RNA genome. This is carried out by the viral RNA-dependent RNA polymerase. The mRNA is then used as a template for protein synthesis, which is necessary for the production of new viral particles.
Classification[edit | edit source]
Negative-sense ssRNA viruses are classified into several families, including the Orthomyxoviridae (which includes the Influenza virus), Paramyxoviridae (which includes Measles virus and Mumps virus), and Rhabdoviridae (which includes Rabies virus).
Diseases[edit | edit source]
Negative-sense ssRNA viruses are responsible for a number of diseases in humans and animals. For example, the Influenza virus causes influenza, the Measles virus causes measles, and the Rabies virus causes rabies.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
