Neuropeptides B/W receptor 2

From WikiMD's Food, Medicine & Wellness Encyclopedia

Neuropeptides B/W receptor 2 (NPBWR2), also known as G protein-coupled receptor 8 (GPR8), is a protein that in humans is encoded by the NPBWR2 gene. This receptor is a member of the ghrelin receptor family and is primarily expressed in the central nervous system (CNS).

Function[edit | edit source]

NPBWR2 is a receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, metabolism, and feeding behavior. The activation of NPBWR2 by its ligands leads to the stimulation of intracellular calcium release and synaptic transmission in the CNS.

Clinical significance[edit | edit source]

Alterations in the NPBWR2 gene have been associated with susceptibility to obesity and eating disorders. Further research is needed to fully understand the role of NPBWR2 in these conditions.

See also[edit | edit source]

References[edit | edit source]


‎ ‎


Wiki.png

Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD


Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD

WikiMD is not a substitute for professional medical advice. See full disclaimer.

Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD