Ovarian carcinosarcoma
Other Names: Malignant mixed mullerian tumor of the ovary; Malignant mixed Müllerian tumor of the ovary; MMMT of the ovary; Ovarian malignant mixed Müllerian tumor; Ovarian malignant mixed epithelial mesenchymal tumor
Ovarian carcinosarcoma, also known as a malignant mixed mullerian tumor (MMMT) of the ovary, is a rare, aggressive cancer of the ovary with characteristics of two types of cancer: carcinoma and sarcoma. Because women with this cancer often have no symptoms, more than half of women are diagnosed at an advanced stage.
Cause[edit | edit source]
The cause of ovarian carcinosarcoma is not yet understood.
Inheritance[edit | edit source]
Ovarian carcinosarcoma is not thought to be due to an inherited gene mutation. We are aware of one report of a woman with a BRCA2 gene mutation who developed ovarian carcinosarcoma. However, to our knowledge, this cancer typically occurs in women with no family history of ovarian carcinoma or a hereditary cancer syndrome.
Signs and symptoms[edit | edit source]
When present, symptoms may include pain in the abdomen or pelvic area, bloating or swelling of the abdomen, quickly feeling full when eating, or other digestive problems.
Diagnosis[edit | edit source]
The initial approach to diagnosis includes patient’s history, physical examination, blood tests, tumor markers (CEA, CA-125) and additionally in the presence of previous histological confirmation: chest radiography, mammography, gastroscopy and colonoscopy, ultrasound and/or CT scan of the abdomen.
Treatment[edit | edit source]
Because ovarian carcinosarcoma is rare, there are no established treatment guidelines. Treatment decisions are based on the unique features of each individual's diagnosis. The National Comprehensive Cancer Network (NCCN), a group of physicians and researchers who strive to improve cancer care, recommends that women with ovarian carcinosarcoma be treated similarly to women with ovarian carcinoma (also called epithelial ovarian cancer), which is the most common type of ovarian cancer.
Currently, treatment for ovarian carcinosarcoma usually begins with surgery to remove as much of the cancer as possible. Chemotherapy may be used to destroy any cancer cells that could be in the body after surgery. Medications that contain platinum (such as cisplatin or carboplatin) seem to be the most effective chemotherapies for ovarian carcinosarcoma. Recent evidence suggests that another medication called ifosfamide may increase the effectiveness of treatment when used in combination with platinum-based medications.
Prognosis[edit | edit source]
The prognosis is poor and the median overall survival is around 20 months. There are reports in the literature with survival over 46 months.
NIH genetic and rare disease info[edit source]
Ovarian carcinosarcoma is a rare disease.
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