Repaglinide

Information about Repaglinide[edit source]

Repaglinide is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes.

Liver safety of Repaglinide[edit source]

Repaglinide has been linked to rare instances of clinically apparent acute liver injury.

Mechanism of action of Repaglinide[edit source]

Repaglinide (re pag' li nide) is an insulin secretagogue that is similar in action but different in structure from the sulfonylureas. It is a benzoid acid derivative that, like the sulfonylureas, stimulates insulin secretion by blocking ATP sensitive potassium channels in pancreatic beta-cells, causing cell membrane depolarization which results in calcium influx and insulin secretion. Repaglinide has been shown to reduce the postprandial increase in glucose in patients with type 2 diabetes and improve glycemic control. Repaglinide

FDA approval information for Repaglinide[edit source]

Repaglinide was approved for use in the United States in 1997. The current indications are for management of type 2 diabetes used in combination with diet and exercise, with or without other oral hypoglycemic agents.

Brand name for Repaglinide[edit source]

Repaglinide is available generically and under the brand name Prandin in tablets of 0.5, 1 and 2 mg.

Dosage and administration for Repaglinide[edit source]

The typical initial dose in adults is 0.5 mg three times daily before meals, with a gradual increase to a maximum of 16 mg daily.

Side effects of Repaglinide[edit source]

Side effects of repaglinide include diarrhea, nausea, gastrointestinal upset, hypoglycemia, headache, dizziness, arthralgia and rash.

Antidiabetics

Alpha-Glucosidase Inhibitors
- Acarbose
- Miglitol
Incretin-Based Drugs
- Dipeptidyl Peptidase-4 (DPP-4) Inhibitors
- Glucagon-Like Peptide-1 (GLP-1) Analogues
Insulin
Metformin
Metiglinide Analogues
- Nateglinide
- Repaglinide
Pramlintide
Sodium Glucose Cotransporter-2 (SGLT-2) Inhibitors
Sulfonylureas
- First Generation Sulfonylureas
  - Acetohexamide
  - Chlorpropamide
  - Tolazamide
  - Tolbutamide
- Second Generation Sulfonylureas
  - Gliclazide
  - Glimepiride
  - Glipizide
  - Glyburide (Glibenclamide)
Thiazolidinediones

Repaglinide Resources
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