Necrobiotic xanthogranuloma

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Alternate names[edit | edit source]

NXG

Definition[edit | edit source]

Necrobiotic xanthogranuloma (NXG) is a rare, chronic form of non-Langerhans histiocytosis usually found in older adults. Xanthogranulomas are lesions made of immune cells known as a histiocytes. The term necrobiotic refers to the buildup of broken down collagen fibers that can be seen under a microscope.

Signs and symptoms[edit | edit source]

  • The typical lesion is a yellow, thickened, or raised lesion (plaque) located around the eyes.
  • In most cases the lesions are associated with conditions in which abnormal proteins are found in the blood (monoclonal gammopathies).
  • NXG is also sometimes associated with blood cancers or lymphoproliferative disorders.
  • As these blood disorders may arise years after the first NXG lesions appear, lifelong follow-up may be recommended.
  • Approximately 50% of people with NXG have problems with their eyes, such as burning or itching, blurred vision, double vision, bulging of the eyeball, drooping of the eyelid, and restricted eye movement.
  • In most cases, other parts of the body, such as the trunk, legs, face, and arms, are also involved.
  • Internal organs may sometimes be affected.

Treatment[edit | edit source]

See also[edit | edit source]

External links[edit | edit source]

Classification
External resources


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