Tecadenoson

Tecadenoson.svg

Tecadenoson is a selective adenosine A1 receptor agonist that has been investigated for its potential use in the treatment of supraventricular tachycardia (SVT) and other cardiac arrhythmias. It is a synthetic compound that mimics the action of the endogenous nucleoside adenosine, which plays a crucial role in cardiovascular physiology.

Mechanism of Action

Tecadenoson works by selectively binding to the adenosine A1 receptors, which are G-protein coupled receptors located primarily in the heart. Activation of these receptors leads to a decrease in adenylate cyclase activity, resulting in reduced levels of cyclic AMP (cAMP). This cascade of events ultimately leads to a decrease in heart rate and atrioventricular (AV) node conduction velocity, making it useful in the management of SVT.

Pharmacokinetics

Tecadenoson is administered intravenously, allowing for rapid onset of action. It has a short half-life, which is beneficial in clinical settings where quick reversal of effects is desired. The drug is metabolized primarily in the liver and excreted in the urine.

Clinical Trials

Tecadenoson has undergone several clinical trials to evaluate its efficacy and safety in treating SVT. Results have shown that it can effectively slow AV node conduction and terminate episodes of SVT. However, its development has been limited due to concerns about side effects and the availability of other therapeutic options.

Side Effects

Common side effects of tecadenoson include bradycardia, hypotension, and dizziness. These effects are generally mild and transient, but they can be more pronounced in certain populations, such as those with pre-existing cardiac conditions.

Current Status

As of the latest updates, tecadenoson is not approved for clinical use in most countries. Research continues to explore its potential applications and to develop formulations that minimize side effects.

Also see

• Adenosine (medication)
• Supraventricular tachycardia
• Adenosine receptor
• Cardiac arrhythmia

Cardiovascular disease A-Z

Most common cardiac diseases

• Cardiac arrhythmia‎
• Cardiogenetic disorders‎
• Cardiomegaly‎
• Cardiomyopathy‎
• Cardiopulmonary resuscitation‎
• Chronic rheumatic heart diseases‎
• Congenital heart defects‎
• Heart neoplasia‎
• Ischemic heart diseases‎
• Pericardial disorders
• Syndromes affecting the heart‎
• Valvular heart disease‎

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z

A

• Accelerated idioventricular rhythm
• Acute decompensated heart failure
• Arteriosclerotic heart disease
• Athletic heart syndrome
• Atrial flutter
• Atrioventricular fistula
• Cardiovascular disease in Australia
• Autoimmune heart disease

B

• Brown atrophy of the heart

C

• Ebb Cade
• Cardiac allograft vasculopathy
• Cardiac amyloidosis
• Cardiac asthma
• Cardiac tamponade
• Cardiogenic shock
• Cardiogeriatrics
• Cardiorenal syndrome
• Cardiotoxicity
• Carditis
• Coronary artery aneurysm
• Coronary artery anomaly
• Coronary artery disease
• Spontaneous coronary artery dissection
• Coronary artery ectasia
• Coronary occlusion
• Coronary steal
• Coronary thrombosis
• Coronary vasospasm
• Cœur en sabot
• Coxsackievirus-induced cardiomyopathy

D

• Duke Treadmill Score
• Duroziez's disease

E

• Eisenmenger's syndrome
• Embryocardia
• Endocardial fibroelastosis
• Eosinophilic myocarditis

H

• Heart attack
• Heart failure
• Heart failure with preserved ejection fraction
• Heart to Heart (1949 film)
• High-output heart failure
• Hyperdynamic precordium

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z

I

• Idiopathic giant-cell myocarditis
• Interventricular dyssynchrony
• Intraventricular dyssynchrony
• Isolated atrial amyloidosis

K

• Keshan disease

L

• Loeffler endocarditis

M

• Mydicar
• Myocardial bridge
• Myocardial disarray
• Myocardial rupture
• Myocardial scarring
• Myocardial stunning
• Myocarditis

N

• Nonbacterial thrombotic endocarditis

O

• OLR1
• Ostial disease

P

• Papillary fibroelastoma
• Pathophysiology of heart failure
• Postpericardiotomy syndrome
• Pulmonary vein stenosis

R

• Right axis deviation
• Roemheld syndrome

S

• Saturated fat and cardiovascular disease
• SCAR-Fc
• Shone's syndrome
• Strain pattern
• Subacute bacterial endocarditis
• Sudden cardiac death of athletes

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z

T

• Traumatic cardiac arrest

V

• Ventricular aneurysm
• Vibroacoustic disease
• Viral cardiomyopathy

W

• Waon therapy