VU-001,171
VU-001,171 is a chemical compound that acts as a selective positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4). It has been studied for its potential therapeutic effects in various neurological disorders, including Parkinson's disease and anxiety disorders.
Mechanism of Action[edit | edit source]
VU-001,171 functions by binding to an allosteric site on the mGluR4 receptor, which is distinct from the orthosteric site where the endogenous ligand, glutamate, binds. This binding enhances the receptor's response to glutamate, thereby modulating neurotransmission in the central nervous system. The mGluR4 receptor is part of the group III metabotropic glutamate receptors, which are primarily involved in the inhibition of neurotransmitter release.
Pharmacological Effects[edit | edit source]
Studies have shown that VU-001,171 can modulate synaptic transmission and has potential neuroprotective effects. In preclinical models, it has demonstrated efficacy in reducing motor symptoms associated with Parkinson's disease by modulating the basal ganglia circuitry. Additionally, its anxiolytic properties have been observed in animal models, suggesting potential use in treating anxiety disorders.
Research and Development[edit | edit source]
VU-001,171 is primarily used as a research tool to study the function of mGluR4 and its role in various neurological conditions. It has provided insights into the therapeutic potential of targeting mGluR4 in diseases characterized by dysregulated glutamatergic transmission.
Safety and Toxicology[edit | edit source]
As a research compound, the safety profile of VU-001,171 in humans is not well-established. Preclinical studies have focused on its efficacy and mechanism of action, with limited data on long-term safety and potential side effects.
Also see[edit | edit source]
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Contributors: Prab R. Tumpati, MD
