Valganciclovir hydrochloride

Valganciclovir Hydrochloride is an antiviral medication used primarily in the treatment of cytomegalovirus (CMV) infections. It is a prodrug, meaning it is converted in the body into the active drug, ganciclovir.

Pharmacology

Valganciclovir Hydrochloride is rapidly converted into ganciclovir in the intestines, liver, and blood plasma. Ganciclovir then inhibits the replication of cytomegalovirus by competitively binding to DNA polymerase, an enzyme necessary for the virus to reproduce.

Uses

Valganciclovir Hydrochloride is used to treat and prevent diseases caused by cytomegalovirus. This includes retinitis, which can lead to blindness in people with AIDS, and organ transplant patients who are at risk of systemic CMV disease. It is also used in the treatment of congenital CMV infections in newborns.

Side Effects

Common side effects of Valganciclovir Hydrochloride include nausea, diarrhea, and anemia. More serious side effects can include neutropenia, where the body has abnormally low levels of neutrophils, a type of white blood cell.

Precautions

Patients with impaired kidney function may need to have their dose adjusted, as Valganciclovir Hydrochloride is primarily excreted in the urine. It is also known to cause birth defects and should not be used during pregnancy unless the potential benefits outweigh the risks.

See Also

• Antiviral drug
• Cytomegalovirus
• Ganciclovir