(Nphe1)Nociceptin(1-13)NH2
Overview[edit | edit source]
(Nphe1)Nociceptin(1-13)NH2 is a synthetic peptide analog of the endogenous neuropeptide nociceptin, also known as orphanin FQ. Nociceptin is a 17-amino acid peptide that acts as a ligand for the nociceptin receptor (NOP receptor), which is part of the opioid receptor family. The modification of the nociceptin peptide by replacing the first amino acid with N-phenylalanine (Nphe) and truncating the peptide to 13 amino acids with an amide group at the C-terminus results in (Nphe1)Nociceptin(1-13)NH2.
Structure[edit | edit source]
The structure of (Nphe1)Nociceptin(1-13)NH2 is derived from the native nociceptin peptide. The sequence is modified as follows:
- Nphe1: N-phenylalanine replaces the first amino acid, phenylalanine, in the native sequence.
- The peptide is truncated to 13 amino acids.
- An amide group is added to the C-terminus, resulting in the NH2 group.
This modification is designed to enhance the peptide's stability and affinity for the NOP receptor.
Mechanism of Action[edit | edit source]
(Nphe1)Nociceptin(1-13)NH2 acts as an agonist at the nociceptin receptor. The NOP receptor is a G protein-coupled receptor (GPCR) that is involved in modulating pain, mood, and other physiological processes. Upon binding to the NOP receptor, (Nphe1)Nociceptin(1-13)NH2 activates intracellular signaling pathways that can lead to analgesic effects, among other outcomes.
Pharmacological Effects[edit | edit source]
Research on (Nphe1)Nociceptin(1-13)NH2 has shown that it can produce various pharmacological effects, including:
- Analgesia: It can modulate pain perception by acting on the central nervous system.
- Anxiolytic effects: It may reduce anxiety-like behaviors in animal models.
- Modulation of reward pathways: It can influence reward-related behaviors, potentially impacting addiction and substance use disorders.
Research and Applications[edit | edit source]
(Nphe1)Nociceptin(1-13)NH2 is primarily used in research settings to study the function of the NOP receptor and its role in various physiological and pathological processes. It serves as a tool for understanding the nociceptin system and developing potential therapeutic agents targeting the NOP receptor.
Also see[edit | edit source]
Template:Receptor pharmacology
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