Briumvi
- BRIUMVI™(Ublituximab) is an intravenous injection treatment for relapsing forms of multiple sclerosis (MS) in adults.
- It is a CD20-directed cytolytic antibody that was first approved in the U.S. in 2022.
Screening[edit | edit source]
- Before using BRIUMVI, patients must be screened for hepatitis B virus and have a quantitative serum immunoglobulin screening.
- They should also pre-medicate with methylprednisolone and an antihistamine before each infusion.
Dosage[edit | edit source]
- The BRIUMVI dosage is 150 mg for the first infusion, 450 mg for the second infusion two weeks later, and 450 mg for subsequent infusions every 24 weeks.
- BRIUMVI should be diluted with 0.9% Sodium Chloride Injection before administration, and patients should be monitored closely during and after the first two infusions.
Contraindications[edit | edit source]
- BRIUMVI is contraindicated for those with active hepatitis B virus infection or a history of life-threatening infusion reactions to the treatment.
- Infusion reactions and infections, including serious and potentially fatal infections, may occur during treatment.
- Patients should avoid live-attenuated or live vaccines while on BRIUMVI and for some time after stopping it.
- The level of immunoglobulins should also be monitored, and BRIUMVI may be discontinued if serious opportunistic or recurrent infections occur.
- BRIUMVI can also cause fetal harm, so females of reproductive potential should be advised to use effective contraception during treatment and for at least 6 months after stopping it.
Side effects[edit | edit source]
Common adverse reactions include infusion reactions and upper respiratory tract infections.
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Contributors: Prab R. Tumpati, MD