Clopenthixol decanoate

Clopenthixol decanoate is a typical antipsychotic drug of the thioxanthene class, which is used in the treatment of schizophrenia and other psychotic disorders. It is a long-acting, injectable derivative of clopenthixol, and is administered intramuscularly.

Pharmacology

Clopenthixol decanoate is a dopamine antagonist. It works by blocking dopamine receptors in the brain, which helps to reduce the symptoms of psychosis. The drug is a lipophilic compound, which allows it to be stored in body fat and released slowly over time. This makes it suitable for long-term treatment of chronic conditions such as schizophrenia.

Clinical use

Clopenthixol decanoate is used primarily in the treatment of schizophrenia, but it may also be used for other psychotic disorders when other treatments have failed. It is typically administered by intramuscular injection every 1-4 weeks, depending on the patient's response and the severity of their symptoms. The drug has a slow onset of action, with effects typically beginning to be felt after 24-48 hours.

Side effects

Like other antipsychotic drugs, clopenthixol decanoate can cause a range of side effects. These may include drowsiness, dizziness, dry mouth, constipation, and blurred vision. More serious side effects can include tardive dyskinesia, a condition characterized by involuntary movements, and neuroleptic malignant syndrome, a potentially life-threatening reaction to antipsychotic drugs.

See also

• Antipsychotic
• Schizophrenia
• Psychosis
• Dopamine antagonist