Ezetimibe + Simvastatin

What Is Ezetimibe + Simvastatin

• Ezetimibe + Simvastatin (Vytorin) which contains a cholesterol absorption inhibitor(Ezetimibe) and an HMG-CoA reductase inhibitor (Simvastatin a statin drug).

What are the uses of this medicine?

• This medication is is indicated as adjunctive therapy to diet to:

•reduce elevated total-C, LDL-C, Apo B, TG, and non-HDL-C, and to increase HDL-C in patients with primary (heterozygous familial and non-familial) hyperlipidemia or mixed hyperlipidemia. •reduce elevated total-C and LDL-C in patients with homozygous familial hypercholesterolemia (HoFH), as an adjunct to other lipid lowering treatments.

Who Should Not Use Ezetimibe + Simvastatin ?

• Hypersensitivity to any component of this medication
• Active liver disease or unexplained persistent elevations of hepatic transaminase levels
• Women who are pregnant or may become pregnant
• Nursing mothers

Is this medicine FDA approved

• Generic versions were approved in 2017.
• The combination preparation is marketed by Merck & Co. under the trade names Vytorin in the US and Inegy in the European Union.
• In 2017, it was the 298th most commonly prescribed medication in the United States, with more than one million prescriptions.

How should this medicine be used?

• The usual dosage range is 10/10 mg/day to 10/40 mg/day.
• The recommended usual starting dose is 10/10 mg/day or 10/20 mg/day.
• Vytorin should be taken as a single daily.

What are the dosage forms and brand names of this medicine?

This medicine is available in following dosage forms:

• Vytorin ® 10/10, (ezetimibe 10 mg and simvastatin 10 mg tablets)
• Vytorin ® 10/20, (ezetimibe 10 mg and simvastatin 20 mg tablets)
• Vytorin ® 10/40, (ezetimibe 10 mg and simvastatin 40 mg tablets)
• Vytorin ® 10/80, (ezetimibe 10 mg and simvastatin 80 mg tablets)

This medicine is available in following brand names:

• Vytorin ®

What side effects can this medication cause?

Common possible side effects of fluoxetine include:

• myopathy
• rhabdomyolysis
• persistent muscle pain, tenderness, or weakness
• Pain in extremities, abdomen
• Angioedema
• Hepatitis
• Eczema
• Fatigue
• Headache
• Influenza, pharyngitis, sinusitis and upper respiratory tract infection

Adverse reactions may include:

• headache
• increased ALT
• myalgia
• upper respiratory tract infection
• diarrhea

What special precautions should I follow?

• Patients should be advised of the increased risk of myopathy, including rhabdomyolysis.
• Patients should be advised to report promptly any unexplained and/or persistent muscle pain, tenderness, or weakness.
• This medicine should be discontinued immediately if myopathy is diagnosed or suspected.
• Check liver enzyme tests before initiating therapy and as clinically indicated there after.

What to do in case of emergency/overdose?

• No specific treatment of overdosage with Vytorin can be recommended.
• In the event of an overdose, symptomatic and supportive measures should be employed.

Can this medicine be used in pregnency?

• Vytorin is contraindicated in women who are or may become pregnant.
• Lipid-lowering drugs offer no benefit during pregnancy, because cholesterol and cholesterol derivatives are needed for normal fetal development.

What should I know about storage and disposal of this medication?

• Store at 20-25°C (68-77°F).
• Keep container tightly closed.
• Store in original container until time of use.
• When product container is subdivided, repackage into a tightly-closed, lightresistant container.
• Entire contents must be repackaged immediately upon opening.

• Dailymed label info on Ezetimibe + Simvastatin
• FDA Ezetimibe + Simvastatin

Ezetimibe + Simvastatin Resources
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Ezetimibe + Simvastatin Resources
Latest articles Most recent articles Ongoing trials	Wikipedia