Ezetimibe + Simvastatin
What Is Ezetimibe + Simvastatin [edit | edit source]
- Ezetimibe + Simvastatin (Vytorin) which contains a cholesterol absorption inhibitor(Ezetimibe) and an HMG-CoA reductase inhibitor (Simvastatin a statin drug).
What are the uses of this medicine?[edit | edit source]
- This medication is is indicated as adjunctive therapy to diet to:
•reduce elevated total-C, LDL-C, Apo B, TG, and non-HDL-C, and to increase HDL-C in patients with primary (heterozygous familial and non-familial) hyperlipidemia or mixed hyperlipidemia. •reduce elevated total-C and LDL-C in patients with homozygous familial hypercholesterolemia (HoFH), as an adjunct to other lipid lowering treatments.
Who Should Not Use Ezetimibe + Simvastatin ?[edit | edit source]
- Hypersensitivity to any component of this medication
- Active liver disease or unexplained persistent elevations of hepatic transaminase levels
- Women who are pregnant or may become pregnant
- Nursing mothers
Is this medicine FDA approved[edit | edit source]
- Generic versions were approved in 2017.
- The combination preparation is marketed by Merck & Co. under the trade names Vytorin in the US and Inegy in the European Union.
- In 2017, it was the 298th most commonly prescribed medication in the United States, with more than one million prescriptions.
How should this medicine be used?[edit | edit source]
- The usual dosage range is 10/10 mg/day to 10/40 mg/day.
- The recommended usual starting dose is 10/10 mg/day or 10/20 mg/day.
- Vytorin should be taken as a single daily.
What are the dosage forms and brand names of this medicine?[edit | edit source]
This medicine is available in following dosage forms:
- Vytorin ® 10/10, (ezetimibe 10 mg and simvastatin 10 mg tablets)
- Vytorin ® 10/20, (ezetimibe 10 mg and simvastatin 20 mg tablets)
- Vytorin ® 10/40, (ezetimibe 10 mg and simvastatin 40 mg tablets)
- Vytorin ® 10/80, (ezetimibe 10 mg and simvastatin 80 mg tablets)
This medicine is available in following brand names:
- Vytorin ®
What side effects can this medication cause?[edit | edit source]
Common possible side effects of fluoxetine include:
- myopathy
- rhabdomyolysis
- persistent muscle pain, tenderness, or weakness
- Pain in extremities, abdomen
- Angioedema
- Hepatitis
- Eczema
- Fatigue
- Headache
- Influenza, pharyngitis, sinusitis and upper respiratory tract infection
Adverse reactions may include:
What special precautions should I follow?[edit | edit source]
- Patients should be advised of the increased risk of myopathy, including rhabdomyolysis.
- Patients should be advised to report promptly any unexplained and/or persistent muscle pain, tenderness, or weakness.
- This medicine should be discontinued immediately if myopathy is diagnosed or suspected.
- Check liver enzyme tests before initiating therapy and as clinically indicated there after.
What to do in case of emergency/overdose?[edit | edit source]
- No specific treatment of overdosage with Vytorin can be recommended.
- In the event of an overdose, symptomatic and supportive measures should be employed.
Can this medicine be used in pregnency?[edit | edit source]
- Vytorin is contraindicated in women who are or may become pregnant.
- Lipid-lowering drugs offer no benefit during pregnancy, because cholesterol and cholesterol derivatives are needed for normal fetal development.
What should I know about storage and disposal of this medication?[edit | edit source]
- Store at 20-25°C (68-77°F).
- Keep container tightly closed.
- Store in original container until time of use.
- When product container is subdivided, repackage into a tightly-closed, lightresistant container.
- Entire contents must be repackaged immediately upon opening.
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Ezetimibe + Simvastatin Resources | ||
---|---|---|
|
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Translate to: East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski
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