Erythromelalgia

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(Redirected from Red neuralgia)

Erythromelalgia in hands of a Scandinavian male, 52, after holding a book).
Toes during an EM flareup
Sir Thomas Barlow

Erythromelalgia[edit | edit source]

Erythromelalgia, formerly known as Mitchell's disease (named after Silas Weir Mitchell), is a rare vascular peripheral pain disorder. This condition leads to the episodic blocking of blood vessels, typically in the lower extremities or hands, which subsequently become inflamed and hyperemic.

Definition[edit | edit source]

Erythromelalgia is a disorder characterized by:

  • Intense burning pain.
  • Redness (erythema).
  • Increased temperature in the affected areas.
  • Episodes of symptom exacerbation and relief.

History[edit | edit source]

The condition was first described by Dr. Silas Weir Mitchell in the 19th century, hence the former name Mitchell's disease.

Pathophysiology[edit | edit source]

The exact cause of erythromelalgia remains unclear, but it is believed to result from:

  • Abnormalities in the normal vasomotor responses or functioning of the blood vessels.
  • Possible genetic mutations in some cases.

Symptoms[edit | edit source]

Main symptoms include:

  • Intense burning or throbbing pain.
  • Swelling or inflammation of the affected region.
  • Increased warmth and redness in the affected areas.
  • Episodes that may last from minutes to hours or even longer.

Diagnosis[edit | edit source]

Diagnosis is primarily clinical, based on:

  • Detailed medical history.
  • Physical examination.
  • Exclusion of other conditions.

In some cases, a skin biopsy or other tests might be performed to rule out other disorders.

Treatment[edit | edit source]

There is no definitive cure for erythromelalgia, but treatments aim to relieve symptoms. Common approaches include:

  • Cooling the affected area.
  • Avoiding triggers such as heat or specific activities.
  • Pain relievers like NSAIDs or aspirin.
  • Topical creams or patches.
  • Certain anticonvulsants or antidepressants.

Epidemiology[edit | edit source]

Erythromelalgia is a rare condition, with a variable reported incidence. It can affect people of all ages but may be more common in certain age groups.

See Also[edit | edit source]

Footnotes[edit | edit source]

External links[edit | edit source]

Classification
External resources


Erythromelalgia Resources
Wikipedia


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Contributors: Prab R. Tumpati, MD