Zetidoline
An antipsychotic medication
Zetidoline is a chemical compound that has been investigated for its potential use as an antipsychotic medication. It belongs to the class of benzothiophene derivatives and has been studied for its effects on the central nervous system.
Pharmacology[edit | edit source]
Zetidoline acts primarily as a dopamine receptor antagonist, which means it blocks the action of dopamine, a neurotransmitter that is involved in mood, behavior, and cognition. By inhibiting dopamine receptors, particularly the D2 subtype, zetidoline may help to alleviate symptoms of schizophrenia and other psychotic disorders.
Clinical Trials[edit | edit source]
Clinical trials of zetidoline have been conducted to evaluate its efficacy and safety in treating psychotic disorders. These studies have shown that zetidoline can reduce symptoms such as hallucinations, delusions, and disorganized thinking. However, like many antipsychotics, it may also cause side effects, including sedation, weight gain, and extrapyramidal symptoms.
Side Effects[edit | edit source]
The side effects of zetidoline are similar to those of other antipsychotic medications. Common side effects include:
- Sedation: Patients may experience drowsiness or lethargy.
- Weight gain: Increased appetite and weight gain are possible.
- Extrapyramidal symptoms: These include tremors, rigidity, and bradykinesia, which are similar to symptoms of Parkinson's disease.
Mechanism of Action[edit | edit source]
Zetidoline's mechanism of action involves the blockade of dopamine receptors in the brain. By reducing the activity of dopamine, it helps to balance neurotransmitter levels and reduce psychotic symptoms. This mechanism is similar to that of other typical antipsychotics.
History[edit | edit source]
Zetidoline was first synthesized in the late 20th century as part of efforts to develop new antipsychotic medications. Although it showed promise in early studies, it has not been widely adopted in clinical practice, possibly due to the availability of other antipsychotics with more favorable side effect profiles.
Also see[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
