Micafungin

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(Redirected from Micafungin sodium)

What is Micafungin?[edit | edit source]


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Micafungin
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Micafungin ball-and-stick



What are the uses of this medicine?[edit | edit source]

Micafungin (Mycamine) is used in adult and pediatric patients for:

Limitations of Use:


How does this medicine work?[edit | edit source]

  • Micafungin is a member of the echinocandin class of antifungal agents.
  • Micafungin inhibits the synthesis of 1,3-beta-D-glucan, an essential component of fungal cell walls, which is not present in mammalian cells.
  • The echinocandins are a relatively new class of antifungal agents, whose activity is due to inhibition of glucan synthetase, the enzyme that is responsible for synthesis of β-1, 3-D-glucan, an essential component of the cell wall of filamentous fungi, such as Aspergillus and Candida species.
  • This enzyme inhibition results in alteration in the fungal membrane integrity, followed by cell ballooning and, for Candida cells, lysis.


Who Should Not Use this medicine ?[edit | edit source]

This medicine cannot be used in patients with:


What drug interactions can this medicine cause?[edit | edit source]


Is this medicine FDA approved?[edit | edit source]

  • Micafungin was approved for use in the United States in 2005.


How should this medicine be used?[edit | edit source]

Recommended dosage: Treatment of Candidemia, Acute Disseminated Candidiasis, Candida Peritonitis and Abscesses:

  • Adult:100 mg daily
  • Pediatric Patients (4 Months and Older 30 kg or less): 2 mg/kg/day (maximum 100 mg daily)
  • Pediatric Patients (4 Months and Older greater than 30 kg): 2 mg/kg/day (maximum 100 mg daily)
  • Pediatric Patients Younger than 4 Months of Age: 4 mg/kg/day

Treatment of Candidemia, Acute Disseminated Candidiasis, Candida Peritonitis and Abscesses without Meningoencephalitis and/or Ocular Dissemination :

  • Adult:100 mg daily
  • Pediatric Patients (4 Months and Older 30 kg or less): 2 mg/kg/day (maximum 100 mg daily)
  • Pediatric Patients (4 Months and Older greater than 30 kg): 2 mg/kg/day (maximum 100 mg daily)
  • Pediatric Patients Younger than 4 Months of Age: 4 mg/kg/day

Treatment of Esophageal Candidiasis:

  • Adult:150 mg daily
  • Pediatric Patients (4 Months and Older 30 kg or less):3 mg/kg/day
  • Pediatric Patients (4 Months and Older greater than 30 kg):2.5 mg/kg/day(maximum 150 mg daily)
  • Pediatric Patients Younger than 4 Months of Age: Not approved

Prophylaxis of Candida Infections in HSCT Recipients:

  • Adult:50 mg daily
  • Pediatric Patients (4 Months and Older 30 kg or less):1 mg/kg/day (maximum 50 mg daily)
  • Pediatric Patients (4 Months and Older greater than 30 kg):1 mg/kg/day (maximum 50 mg daily)
  • Pediatric Patients Younger than 4 Months of Age: Not approved


Administration:

  • Administer MYCAMINE by intravenous infusion only.
  • Infuse over one hour.
  • More rapid infusions may result in more frequent histamine-mediated reactions.

Pediatric Patients:

  • MYCAMINE should be infused over one hour. To decrease the risk of infusion reactions, concentrations above
  • 1.5 mg/mL should be administered via central catheter


What are the dosage forms and brand names of this medicine?[edit | edit source]

This medicine is available in fallowing doasage form:

  • As injection: 50 mg single-dose vial.
  • injection: 100 mg single-dose vial.

This medicine is available in fallowing brand namesː

  • MYCAMINE


What side effects can this medication cause?[edit | edit source]

The most common side effects of this medicine include: In adult and pediatric patients:

In pediatric patients younger than 4 months of age:


What special precautions should I follow?[edit | edit source]

  • Isolated cases of serious hypersensitivity (anaphylaxis and anaphylactoid) reactions (including shock) have been reported in patients receiving MYCAMINE. Discontinue MYCAMINE and administer appropriate treatment.
  • Isolated cases of acute intravascular hemolysis, hemolytic anemia and hemoglobinuria have been reported. Monitor rate of hemolysis. Discontinue if severe.
  • Laboratory abnormalities in liver function tests have been seen in healthy volunteers and patients treated with MYCAMINE. . Monitor hepatic function. Discontinue if severe dysfunction occurs.
  • Elevations in BUN and creatinine, and isolated cases of significant renal impairment or acute renal failure have been reported in patients who received MYCAMINE. Monitor renal function.
  • Infusion and Injection Site Reactions can occur including rash, pruritus, facial swelling, and vasodilatation. Monitor infusion closely, slow infusion rate if necessary.


What to do in case of emergency/overdose?[edit | edit source]

  • In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.


Can this medicine be used in pregnancy?[edit | edit source]

  • Based on findings from animal studies, MYCAMINE may cause fetal harm when administered to a pregnant woman.
  • There is insufficient human data on the use of MYCAMINE in pregnant women to inform a drug-associated risk of adverse developmental outcomes.


Can this medicine be used in children?[edit | edit source]

The safety and effectiveness of MYCAMINE in pediatric patients younger than 4 months of age have not been established for the:


What are the active and inactive ingredients in this medicine?[edit | edit source]

Active ingredient:

  • MICAFUNGIN SODIUM

Inactive Ingredients:

  • none


Who manufactures and distributes this medicine?[edit | edit source]

Manufactured by:

  • Astellas Pharma Tech Co., Ltd. Takaoka Plant
  • 30 Toidesakae-machi, Takaoka city, Toyama , Japan

Marketed by:

  • Astellas Pharma US, Inc.
  • Northbrook, IL USA


What should I know about storage and disposal of this medication?[edit | edit source]

  • Unopened vials of lyophilized material must be stored at room temperature, 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F).
  • Store the reconstituted product at 25°C (77°F).
  • Store the diluted solution at 25°C (77°F).,
  • Protect from light.


Micafungin Resources
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