Nicergoline
Nicergoline (sold under the brand name Sermion among others) is an ergot derivative used to treat senile dementia and other disorders with vascular origins. It has been used internationally for frontotemporal dementia, as well as early onset in Lewy body dementia and Parkinson's disease dementia.
Mechanism of action[edit]
Nicergoline decreases vascular resistance and increases arterial blood flow in the brain, improving the utilization of oxygen and glucose by brain cells. It has similar vasoactive properties in other areas of the body, particularly the lungs.
Safety profile[edit]
Unlike many other ergolines, such as ergotamine, nicergoline is not associated with cardiac fibrosis.
Indications and usage[edit]
Nicergoline is primarily used for the treatment of:
- Senile dementia
- Vascular disorders, including ischemic stroke
- Frontotemporal dementia
- Early onset in Lewy body dementia
- Parkinson's disease dementia
Contraindications[edit]
Nicergoline is contraindicated in patients with a known hypersensitivity to the drug or other ergot derivatives.
Side effects[edit]
Side effects of nicergoline may include:
- Dizziness
- Nausea
- Headache
- Hypotension
- Gastrointestinal discomfort
See also[edit]
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