Yohimbin

Yohimbine is an indole alkaloid derived from the bark of the African tree Pausinystalia johimbe; also from the bark of the unrelated South American tree Aspidosperma quebracho-blanco. Yohimbine is an alpha-2 adrenergic antagonist, and has been used in a variety of research projects. It is a veterinary drug used to reverse sedation in dogs and deer.

Chemistry

Yohimbine is a member of the alkaloid family of compounds. It is classified as an indole alkaloid, which means it contains a core structure of an indole ring. This ring is a bicyclic structure consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring.

Pharmacology

Yohimbine has high affinity for the alpha-2 adrenergic receptor, and is commonly used in scientific research to induce a 'fight or flight' response in animals. It also has a moderate affinity for the serotonin 1A receptor, and a low affinity for the dopamine D2 receptor.

Medical uses

Yohimbine has been used in the treatment of erectile dysfunction. It is thought to work by increasing blood flow to the penis, although the exact mechanism of action is not fully understood. It has also been used to treat hypotension (low blood pressure), as it can increase blood pressure.

Side effects

Common side effects of yohimbine include increased heart rate, high blood pressure, and anxiety. Less common side effects include dizziness, headache, and skin flushing.

See also

• Pausinystalia johimbe
• Aspidosperma quebracho-blanco
• Alpha-2 adrenergic receptor
• Indole

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