CYN-154806

CYN-154806 is a synthetic peptide that acts as a selective antagonist of the melanocortin receptor subtype 4 (MC4R). It is primarily used in research settings to study the physiological and pathological roles of the MC4R, which is involved in the regulation of energy homeostasis, feeding behavior, and body weight.

Structure and Mechanism of Action

CYN-154806 is a cyclic peptide with a specific sequence that allows it to bind selectively to the MC4R. The MC4R is a G protein-coupled receptor (GPCR) that is activated by endogenous melanocortin peptides such as α-MSH (alpha-melanocyte-stimulating hormone). By acting as an antagonist, CYN-154806 inhibits the action of these peptides, thereby blocking the receptor's activity.

Pharmacological Effects

In preclinical studies, CYN-154806 has been shown to:

• Inhibit the anorexigenic effects of MC4R agonists, leading to increased food intake in animal models.
• Modulate energy expenditure and body weight, providing insights into the role of MC4R in obesity and metabolic disorders.
• Affect sexual function and behavior, as MC4R is also expressed in the central nervous system regions involved in these processes.

Research Applications

CYN-154806 is used extensively in research to:

• Investigate the role of MC4R in obesity and metabolic syndrome.
• Study the neural circuits involved in the regulation of appetite and energy balance.
• Explore potential therapeutic targets for the treatment of anorexia nervosa and other eating disorders.

Potential Therapeutic Implications

While CYN-154806 itself is not used clinically, understanding its effects on MC4R can aid in the development of new drugs for conditions such as obesity, cachexia, and sexual dysfunction. By elucidating the pathways and mechanisms involved, researchers can design more effective therapies with fewer side effects.

Safety and Toxicology

As with many investigational compounds, the safety profile of CYN-154806 is primarily characterized in animal models. It is important to note that while it provides valuable insights into MC4R function, its use in humans is limited to research settings.

Also see

• Melanocortin receptor
• G protein-coupled receptor
• Obesity
• Metabolic syndrome
• Peptide therapeutics