Isosorbide dinitrate
(Redirected from Dilatrate-SR)
Nitroglycerin (nye" troe glis' er in) is a propanetriol trinitrate, a nitric oxide prodrug that has been in common use as a treatment for acute angina pectoris for more than 100 years.
Indications (use) - Isosorbide dinitrate[edit source]
Current indications include treatment and prevention of angina attacks and management of acute coronary syndromes. Nitroglycerin is highly volatile and is formulated in a matrix that stabilizes the molecule. However, it is still susceptible to inactivation and is generally provided in a light-proof bottle with a short shelf life (6 months). Nitroglycerin is well absorbed orally but has a high first pass clearance by the liver, for which reason it is typically given sublingually or by transdermal routes. However, nitroglycerin is available generically in many forms, sublingual tablets, topical ointments, transdermal patches, transmucosal ointments, aerosolized sprays, extended release oral tablets and liquid solutions for intravenous use.
Dosage and administration for Isosorbide dinitrate[edit source]
The typical sublingual dose is 0.3 to 0.6 mg at the onset of angina pain or in anticipation of angina. The dose can be repeated every 5 minutes for 15 to 30 minutes for a maximum of 3 doses. The onset of action is within 2 to 5 minutes. The oral and transdermal forms are used largely for prevention of angina and long term therapy.
Side effects of Isosorbide dinitrate[edit source]
Side effects of nitroglycerin include headache, dizziness, weakness, flushing, syncope, tachycardia, palpitations and postural hypotension. Dermal forms can cause local rash and irritation.
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
