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HDL Cholesterol

High-density lipoprotein cholesterol (HDL cholesterol) is one of the five major groups of lipoproteins which enable lipids like cholesterol and triglycerides to be transported within the water-based bloodstream. HDL cholesterol is often referred to as "good cholesterol" due to its function in removing other forms of cholesterol from the bloodstream.

Overview[edit | edit source]

HDL cholesterol is produced by the liver and released into the bloodstream. It circulates in the blood, picking up excess cholesterol from the cells and tissues and carrying it back to the liver for disposal. This process is known as reverse cholesterol transport and is beneficial because it helps to prevent the buildup of plaque in the arteries, a condition known as atherosclerosis.

Function[edit | edit source]

The primary function of HDL cholesterol is to act as a scavenger of excess cholesterol in the bloodstream. It has the ability to bind with cholesterol in the walls of blood vessels and transport it back to the liver. This process helps to prevent the formation of plaque and reduces the risk of heart disease and stroke.

Measurement[edit | edit source]

The level of HDL cholesterol in the blood is measured as part of a lipid panel, a type of blood test commonly performed during physical examinations. The test measures total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides. A higher level of HDL cholesterol is generally associated with a lower risk of heart disease.

Factors Affecting HDL Levels[edit | edit source]

Several factors can affect the level of HDL cholesterol in the blood. These include genetics, diet, exercise, weight, smoking, and alcohol consumption. Certain medications, such as statins, can also affect HDL levels.

See Also[edit | edit source]

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Contributors: Prab R. Tumpati, MD