Hepatic venoocclusive disease
Hepatic venoocclusive disease (HVOD), also known as sinusoidal obstruction syndrome (SOS), is a condition characterized by the obstruction of small veins in the liver. This disease is often associated with chemotherapy and bone marrow transplant procedures, particularly in pediatric patients.
Etiology[edit | edit source]
The exact cause of HVOD is not fully understood. However, it is believed to be related to damage to the cells lining the small veins of the liver, leading to blockage and subsequent liver damage. This damage can be caused by certain medications, particularly high-dose chemotherapy drugs used in the treatment of cancer. Other potential causes include exposure to certain toxins, such as pyrrolizidine alkaloids, found in certain plants and herbs.
Symptoms[edit | edit source]
Symptoms of HVOD can vary in severity, but often include jaundice, ascites (fluid accumulation in the abdomen), and hepatomegaly (enlarged liver). In severe cases, the disease can lead to liver failure and death.
Diagnosis[edit | edit source]
Diagnosis of HVOD is often challenging due to the nonspecific nature of the symptoms. It is typically based on a combination of clinical symptoms, laboratory findings, and imaging studies. Liver biopsy is considered the gold standard for diagnosis, but it is often avoided due to the risk of complications.
Treatment[edit | edit source]
Treatment of HVOD is primarily supportive, focusing on managing symptoms and preventing complications. This may include fluid management, use of diuretics, and treatment of any underlying conditions. In severe cases, liver transplant may be considered.
Prognosis[edit | edit source]
The prognosis of HVOD varies widely, depending on the severity of the disease and the patient's overall health. With prompt diagnosis and treatment, many patients can recover fully. However, in severe cases, the disease can be fatal.
See also[edit | edit source]
 | This medical article is a stub. You can help WikiMD by expanding it. |
This liver disease related article is a stub. You can help WikiMD by expanding it.
This vascular disease related article is a stub. You can help WikiMD by expanding it.
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
