Vascular endothelial growth factor A
Vascular endothelial growth factor A The original member of the family of endothelial cell growth factors referred to as vascular endothelial growth factors. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor".
Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating vasodilation via nitric oxide-dependent pathways.
Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
See also[edit]
- Vascular endothelial growth factor
- Bevacizumab (or Avastin) anti VEGF-A human antibody drug.
This concise article on Vascular endothelial growth factor A incorporates public domain text from the US National Library of Medicine.
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