Mavrilimumab
Mavrilimumab is a human monoclonal antibody that is designed for the treatment of rheumatoid arthritis. It is an immunoglobulin G4, anti-granulocyte macrophage colony-stimulating factor (GM-CSF) receptor α monoclonal antibody. Mavrilimumab was developed by MedImmune, a subsidiary of AstraZeneca.
Mechanism of Action[edit]
Mavrilimumab works by binding to the alpha chain of the GM-CSF receptor, inhibiting GM-CSF signaling. GM-CSF is a cytokine that plays a crucial role in inflammation and autoimmunity, including the pathogenesis of rheumatoid arthritis.
Clinical Trials[edit]
Mavrilimumab has undergone Phase IIb clinical trials for rheumatoid arthritis. The results showed that the drug was well-tolerated and led to improvements in disease activity. It is currently undergoing Phase III trials.
COVID-19 Treatment[edit]
In 2020, mavrilimumab was investigated as a potential treatment for COVID-19. Preliminary results from a small, single-center, open-label study in Italy suggested that mavrilimumab may reduce the risk of respiratory failure and death in patients with severe COVID-19 pneumonia.
See Also[edit]
References[edit]
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