Moxeza

What is Moxeza?

• Moxeza (Moxifloxacin hydrochloride) used for the treatment of bacterial conjunctivitis.

Moxifloxacin skeletal

Moxifloxacin-cation-from-xtal-3D-balls

What are the uses of this medicine?

MOXEZA is used for the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms:

• Aerococcus viridans
• Corynebacterium macginleyi
• Enterococcus faecalis
• Micrococcus luteus
• Staphylococcus arlettae
• Staphylococcus aureus
• Staphylococcus capitis
• Staphylococcus epidermidis
• Staphylococcus haemolyticus
• Staphylococcus hominis
• Staphylococcus saprophyticus
• Staphylococcus warneri
• Streptococcus mitis
• Streptococcus pneumoniae
• Streptococcus parasanguinis
• Escherichia coli
• Haemophilus influenza
• Klebsiella pneumoniae
• Propionibacterium acnes
• Chlamydia trachomatis

How does this medicine work?

• Moxifloxacin is a member of the fluoroquinolone class of anti-infective drugs.
• The antibacterial action of moxifloxacin results from inhibition of the topoisomerase II (DNA gyrase) and topoisomerase IV.
• DNA gyrase is an essential enzyme that is involved in the replication, transcription and repair of bacterial DNA.
• Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division.

Who Should Not Use this medicine ?

• This medicine have no usage limitations.

What drug interactions can this medicine cause?

• No formal drug interaction studies have been conducted with MOXEZA.

Is this medicine FDA approved?

• Moxifloxacin was approved for use in the United States in 1999 and is available generically and under the commercial names of Avelox, Moxeza and Vigamox.

How should this medicine be used?

Recommended dosage:

• Instill 1 drop in the affected eye(s) 2 times daily for 7 days.

Administration:

• Advise patients not to touch the dropper tip to any surface to avoid contaminating the contents.
• Advise patients not to wear contact lenses if they have signs and symptoms of bacterial conjunctivitis.

What are the dosage forms and brand names of this medicine?

This medicine is available in fallowing doasage form:

• As Ophthalmic solution containing moxifloxacin 0.5%.

This medicine is available in fallowing brand namesː

• MOXEZA

What side effects can this medication cause?

The most common side effects of this medicine include:

• eye irritation
• pyrexia
• conjunctivitis

What special precautions should I follow?

• MOXEZA will cause damage to the corneal endothelium if introduced directly into the anterior chamber of the eye.
• Hypersensitivity and anaphylaxis have been reported with systemic use of moxifloxacin. Serious acute hypersensitivity reactions may require immediate emergency treatment. Oxygen and airway management should be administered as clinically indicated.
• As with other anti-infectives, prolonged use may result in overgrowth of non-susceptible organisms, including fungi. If superinfection occurs, discontinue use and institute alternative therapy.
• Patients should be advised not to wear contact lenses if they have signs or symptoms of bacterial conjunctivitis.

What to do in case of emergency/overdose?

• In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.

• Overdose related information is also available online at poisonhelp.org/help.
• In the event that the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services. In the United States, call 911.

Can this medicine be used in pregnancy?

• There are no adequate and well-controlled studies with MOXEZA in pregnant women to inform any drug-associated risks.

Can this medicine be used in children?

• The safety and effectiveness of MOXEZA in infants below 4 months of age have not been established.

What are the active and inactive ingredients in this medicine?

Active ingredient:

• MOXIFLOXACIN HYDROCHLORIDE

Inactive ingredients:

• sodium chloride
• sodium chloride
• xanthan gum
• boric acid
• sorbitol
• tyloxapol
• water
• hydrochloric acid
• sodium hydroxide

Who manufactures and distributes this medicine?

Distributed by:

• Novartis Pharmaceuticals Corporation
• East Hanover, New Jersey

What should I know about storage and disposal of this medication?

• Store at 2°C to 25°C (36°F to 77°F).

• Dailymed label info on Moxeza
• FDA Moxeza

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