5Cl-APINACA
5Cl-APINACA is a synthetic cannabinoid that has been identified as a designer drug. It is a potent agonist of the cannabinoid receptors and is structurally related to other synthetic cannabinoids such as 5F-APINACA and AB-PINACA.
Chemical Structure and Properties[edit | edit source]
5Cl-APINACA belongs to the indazole-3-carboxamide family of synthetic cannabinoids. Its chemical structure is characterized by the presence of a chlorine atom at the 5-position of the indazole ring. The full chemical name is N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(5-chloropentyl)-1H-indazole-3-carboxamide.
Molecular Formula[edit | edit source]
The molecular formula of 5Cl-APINACA is C19H26ClN3O.
Molecular Weight[edit | edit source]
The molecular weight of 5Cl-APINACA is approximately 347.89 g/mol.
Pharmacology[edit | edit source]
5Cl-APINACA acts as a potent agonist at the CB1 and CB2 cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes including mood, memory, and pain sensation.
Effects[edit | edit source]
The effects of 5Cl-APINACA are similar to those of other synthetic cannabinoids and can include euphoria, relaxation, altered perception, and in some cases, anxiety or paranoia. Due to its potency, the risk of adverse effects is significant, especially at higher doses.
Legal Status[edit | edit source]
The legal status of 5Cl-APINACA varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use.
Health Risks[edit | edit source]
The use of 5Cl-APINACA has been associated with a range of adverse health effects, including cardiovascular issues, seizures, and acute psychosis. Long-term health effects are not well understood due to the relatively recent emergence of this compound.
Detection in Biological Samples[edit | edit source]
5Cl-APINACA can be detected in biological samples using techniques such as gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). These methods are used in forensic and clinical toxicology to confirm exposure to the substance.
Also see[edit | edit source]
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Contributors: Prab R. Tumpati, MD
