Dacliximab
Dacliximab is a monoclonal antibody that is used in the treatment of multiple sclerosis. It is a humanized IgG1 monoclonal antibody that binds to CD25, a receptor subunit that is expressed on the surface of T lymphocytes.
Mechanism of Action[edit | edit source]
Dacliximab works by binding to the alpha subunit (CD25) of the high-affinity interleukin-2 receptor on T cells. This binding inhibits the activation of T cells, which are known to play a role in the pathogenesis of multiple sclerosis.
Clinical Use[edit | edit source]
Dacliximab is used in the treatment of relapsing forms of multiple sclerosis. It is administered as a subcutaneous injection once a month.
Side Effects[edit | edit source]
The most common side effects of dacliximab include rash, lymphadenopathy, and nausea. Serious side effects can include liver damage, immune disorders, and infections.
Contraindications[edit | edit source]
Dacliximab is contraindicated in patients with a known hypersensitivity to dacliximab or any of its components. It is also contraindicated in patients with severe liver impairment.
Drug Interactions[edit | edit source]
Dacliximab may interact with other drugs that affect the immune system, such as corticosteroids and immunosuppressants.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
