Estradiol anthranilate, also known as estradiol 3-anthranilate, is a synthetic, steroidal estrogen that is a derivative of estradiol, the primary female sex hormone. It is an estrogen ester, specifically, the 3-anthranilic acid ester of estradiol. Estradiol anthranilate was never marketed.
Chemistry[edit]
Estradiol anthranilate, also known as estra-1,3,5(10)-triene-3,17β-diol 3-anthranilate, is a synthetic estrane steroid and a derivative of estradiol. It is more specifically a derivative of estradiol in which the C3 hydroxyl group has been modified into an anthranilic acid ester.
Pharmacology[edit]
As an estrogen, estradiol anthranilate has similar effects in the body to those of natural estrogens. It can stimulate the development of female secondary sexual characteristics, regulate the menstrual cycle, and influence mood and cognitive function. However, as a synthetic derivative of estradiol, it may have different pharmacokinetics and potency.
History[edit]
Estradiol anthranilate was synthesized in the 1950s as part of a series of estradiol esters. Despite its synthesis, it was never marketed for medical use.
See also[edit]
| Estrogens and antiestrogens |
| Estrogens |
|
| ER
agonists | * Steroidal: Alfatradiol
- Certain androgens/anabolic steroids (e.g., testosterone, testosterone esters, methyltestosterone, metandienone, nandrolone esters) (via estrogenic metabolites)
- Certain progestins (e.g., norethisterone, noretynodrel, etynodiol diacetate, tibolone)
- Clomestrone
- Cloxestradiol acetate
- Conjugated estriol
- Conjugated estrogens
- Epiestriol
- Epimestrol
- Esterified estrogens
- Estetrol†
- Estradiol
- Estradiol esters (e.g., estradiol acetate, estradiol benzoate, estradiol cypionate, estradiol enanthate, estradiol undecylate, estradiol valerate, polyestradiol phosphate, estradiol ester mixtures (Climacteron))
- Estramustine phosphate
- Estriol
- Estriol esters (e.g., estriol succinate, polyestriol phosphate)
- Estrogenic substances
- Estrone
- Estrone esters
- Ethinylestradiol#
- Hydroxyestrone diacetate
- Mestranol
- Methylestradiol
- Moxestrol
- Nilestriol
- Prasterone (dehydroepiandrosterone; DHEA)
- Promestriene
- Quinestradol
- Quinestrol
|
| Progonadotropins | |
|
|
| Antiestrogens |
|
ER
antagonists
(incl. SERMs
/SERDs
) | |
| Aromatase inhibitors | |
| Antigonadotropins | * Androgens/ anabolic steroids (e.g., testosterone, testosterone esters, nandrolone esters, oxandrolone, fluoxymesterone)
- D2 receptor antagonists (prolactin releasers) (e.g., domperidone, metoclopramide, risperidone, haloperidol, chlorpromazine, sulpiride)
- GnRH
agonists (e.g., leuprorelin, goserelin)
- GnRH
antagonists (e.g., cetrorelix, elagolix)
- Progestogens (e.g., chlormadinone acetate, cyproterone acetate, gestonorone caproate, hydroxyprogesterone caproate, medroxyprogesterone acetate, megestrol acetate)
|
| Others | * Mixed mechanism of action: Danazol
|
|
|
|
Estradiol_anthranilate[edit]
