O-1248

O-1248

O-1248 is a synthetic cannabinoid compound that has been studied for its potential effects on the endocannabinoid system. It is a derivative of the well-known cannabinoid receptor agonist, CP-55940, and has been used in scientific research to explore the pharmacological properties of cannabinoids.

Chemical Structure and Properties

O-1248 is chemically related to other synthetic cannabinoids and shares a similar core structure. It is a member of the naphthoylindole family, which is characterized by a naphthalene group linked to an indole moiety. The specific chemical formula of O-1248 is C23H21NO2, and it has a molecular weight of 343.42 g/mol.

The compound is typically synthesized in a laboratory setting and is not found naturally in cannabis plants. Its structure allows it to interact with the cannabinoid receptors in the human body, primarily the CB1 and CB2 receptors, which are part of the endocannabinoid system.

Pharmacology

O-1248 acts as a potent agonist at both CB1 and CB2 receptors. These receptors are G-protein coupled receptors that play a crucial role in modulating neurotransmitter release in the brain and throughout the central and peripheral nervous systems.

• CB1 Receptor: Primarily located in the central nervous system, the CB1 receptor is involved in the regulation of mood, appetite, pain sensation, and memory.
• CB2 Receptor: Found mainly in the peripheral tissues, especially in immune cells, the CB2 receptor is associated with anti-inflammatory effects and immune system modulation.

The binding affinity of O-1248 to these receptors is a subject of research, as it helps in understanding the potential therapeutic applications and side effects of synthetic cannabinoids.

Research and Applications

O-1248 has been used in various preclinical studies to investigate the effects of synthetic cannabinoids on the body. Research has focused on its potential therapeutic uses, such as pain management, anti-inflammatory effects, and neuroprotection.

However, like many synthetic cannabinoids, O-1248 can also produce adverse effects, including psychoactive effects, which limit its use in clinical settings. The compound is primarily used in research to better understand the endocannabinoid system and to develop new therapeutic agents that can target cannabinoid receptors with greater specificity and fewer side effects.

Legal Status

The legal status of O-1248 varies by country. In many jurisdictions, synthetic cannabinoids are controlled substances due to their potential for abuse and lack of medical use. Researchers must obtain special licenses to work with these compounds.

Safety and Toxicology

The safety profile of O-1248 is not well-established, as it is primarily used in laboratory research. Synthetic cannabinoids, in general, can pose significant health risks, including cardiovascular and neurological effects. Caution is advised when handling these compounds in a research setting.

Also see

• Synthetic cannabinoids
• Endocannabinoid system
• CB1 receptor
• CB2 receptor
• Cannabinoid receptor agonists