5F-3-pyridinoylindole

5F-3-pyridinoylindole is a synthetic compound that belongs to the class of indole-based synthetic cannabinoids. These compounds are designed to mimic the effects of tetrahydrocannabinol (THC), the primary psychoactive constituent of cannabis. 5F-3-pyridinoylindole is one of many synthetic cannabinoids that have been developed for research purposes and have sometimes appeared in recreational drug markets.

Chemical Structure and Properties

5F-3-pyridinoylindole is characterized by the presence of a fluorine atom at the 5-position of the indole ring and a pyridinoyl group attached to the 3-position. The general structure of indole-based cannabinoids includes a core indole or indazole ring, which is often substituted with various functional groups to alter its pharmacological properties.

IUPAC Name

The IUPAC name for 5F-3-pyridinoylindole is 1-(5-fluoro-1H-indol-3-yl)-2-(pyridin-3-yl)ethanone.

Molecular Formula

The molecular formula of 5F-3-pyridinoylindole is C₁₆H₁₁FN₂O.

Molecular Weight

The molecular weight of this compound is approximately 266.27 g/mol.

Pharmacology

Synthetic cannabinoids like 5F-3-pyridinoylindole act as agonists at the cannabinoid receptors, primarily the CB1 and CB2 receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes including mood, memory, appetite, and pain sensation.

Mechanism of Action

5F-3-pyridinoylindole binds to the CB1 receptor, which is predominantly found in the central nervous system, and the CB2 receptor, which is more common in peripheral tissues. The binding of synthetic cannabinoids to these receptors can lead to psychoactive effects similar to those of THC, but often with greater potency and unpredictable effects.

Legal Status

The legal status of 5F-3-pyridinoylindole varies by country. Many jurisdictions have moved to ban or regulate synthetic cannabinoids due to their potential for abuse and adverse health effects. It is important to consult local regulations to determine the legal status of this compound in a specific area.

Health Effects and Risks

The use of synthetic cannabinoids, including 5F-3-pyridinoylindole, has been associated with a range of adverse health effects. These can include:

• Tachycardia
• Hypertension
• Anxiety
• Paranoia
• Hallucinations
• Seizures
• Acute kidney injury

Due to the variability in potency and the presence of unknown impurities, the use of synthetic cannabinoids poses significant health risks.

Research and Applications

While synthetic cannabinoids like 5F-3-pyridinoylindole are primarily known for their recreational use, they are also used in scientific research to study the endocannabinoid system and to develop potential therapeutic agents.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• Tetrahydrocannabinol