Ampiroxicam

Ampiroxicam

Ampiroxicam (INN), belonging to the category of non-steroidal anti-inflammatory drugs (NSAIDs), is primarily used to alleviate pain and reduce inflammation. Notably, Ampiroxicam is recognized as a prodrug, meaning it metabolizes in the body to produce another active drug - in this case, piroxicam.

Pharmacology

Mechanism of Action

As with other NSAIDs, Ampiroxicam works by inhibiting enzymes (specifically cyclooxygenase-1 and cyclooxygenase-2) that are involved in the synthesis of molecules (prostaglandins) which mediate inflammation and pain. Upon administration, Ampiroxicam is metabolized into its active form, piroxicam, which then exerts its therapeutic effects.

Metabolism and Excretion

Following oral administration, Ampiroxicam undergoes biotransformation in the liver to produce its active metabolite, piroxicam. This conversion is instrumental for its therapeutic efficacy. Piroxicam is then primarily excreted in the urine, with a small fraction being removed via feces.

Indications

While Ampiroxicam can be used for various inflammatory conditions, its primary indications include:

• Rheumatoid arthritis
• Osteoarthritis
• Painful musculoskeletal conditions
• Other inflammatory joint conditions

Side Effects

As with other NSAIDs, Ampiroxicam can produce a range of side effects, which include, but are not limited to:

• Gastrointestinal issues like ulceration, bleeding, and indigestion
• Dizziness or lightheadedness
• Hypertension (elevated blood pressure)
• Kidney problems
• Prolonged bleeding time

Contraindications

Patients with a history of peptic ulcer disease, those with known hypersensitivity to piroxicam or other NSAIDs, or those with severe renal impairment should avoid using Ampiroxicam.

See Also

• Non-steroidal anti-inflammatory drugs
• Piroxicam
• Pharmacokinetics
• Prodrug