SCUBE1

SCUBE1 is a gene that encodes the Signal peptide, CUB domain and EGF-like domain-containing protein 1. This protein is a member of the SCUBE (Signal peptide, CUB domain, EGF-like) family and plays a crucial role in embryonic development and cell signaling.

Function

The protein encoded by the SCUBE1 gene is a cell surface glycoprotein that is known to complex with integrins. This protein is involved in cell adhesion and migration, and it interacts with platelet-derived growth factors (PDGF) to regulate cell proliferation and differentiation. It is also involved in bone morphogenetic protein (BMP) signaling pathway.

Clinical Significance

Alterations in the SCUBE1 gene have been associated with various diseases. For instance, increased expression of SCUBE1 has been observed in patients with lung cancer and breast cancer, suggesting its potential role as a biomarker for these cancers. Moreover, SCUBE1 has been implicated in cardiovascular diseases such as atherosclerosis and myocardial infarction.

Research

Research on SCUBE1 is ongoing to further understand its functions and implications in various diseases. Current studies are focused on its role in cancer progression and potential as a therapeutic target.

See Also

• SCUBE2
• SCUBE3
• EGF-like domain
• CUB domain
• Signal peptide

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