Gatifloxacin

From WikiMD's Wellness Encyclopedia

(Redirected from Tequin)

What is Gatifloxacin?[edit | edit source]

  • Gatifloxacin (ZYMAXID) ophthalmic solution is a topical fluoroquinolone anti-infective used for the treatment of bacterial conjunctivitis.
Gatifloxacin
Gatifloxacin ball-and-stick


What are the uses of this medicine?[edit | edit source]

  • Gatifloxacin ZYMAXID is used for the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms:

Haemophilus influenzae, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus mitis group, Streptococcus oralis, Streptococcus pneumoniae.


How does this medicine work?[edit | edit source]

  • Gatifloxacin is a fluoroquinolone antibacterial.
  • Gatifloxacin is an 8-methoxyfluoroquinolone with a 3-methylpiperazinyl substituent at C7.
  • The antibacterial action of gatifloxacin results from inhibition of DNA gyrase and topoisomerase IV.
  • DNA gyrase is an essential enzyme that is involved in the replication, transcription, and repair of bacterial DNA.
  • Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division.
  • The mechanism of action of fluoroquinolones including gatifloxacin is different from that of aminoglycoside, macrolide, and tetracycline antibiotics.

Who Should Not Use this medicine ?[edit | edit source]

  • This medicine have no usage limitations.

What drug interactions can this medicine cause?[edit | edit source]

  • Specific drug interaction studies have not been conducted with ZYMAXID® ophthalmic solution.

Is this medicine FDA approved?[edit | edit source]

Initial U.S. Approval: 1999

How should this medicine be used?[edit | edit source]

Recommended dosage: Patients 1 year of age or older:

  • Instill one drop every two hours in the affected eye(s) while awake, up to 8 times on Day 1.
  • Instill one drop two to four times daily in the affected eye(s) while awake on Days 2 through 7.

Administration:

  • Instill one drop two to four times daily in the affected eye(s) while awake.
  • Patients should be instructed to avoid contaminating the applicator tip with material from the eye, fingers, or other source.
  • Patients should be advised not to wear contact lenses if they have signs and symptoms of bacterial conjunctivitis.

What are the dosage forms and brand names of this medicine?[edit | edit source]

This medicine is available in fallowing doasage form:

  • As gatifloxacin ophthalmic solution, 0.5%

This medicine is available in fallowing brand namesː ZYMAXID

What side effects can this medication cause?[edit | edit source]

The most common side effects of this medicine include:

What special precautions should I follow?[edit | edit source]

  • ZYMAXID® solution should not be introduced directly into the anterior chamber of the eye.
  • As with other anti-infectives, prolonged use of ZYMAXID (gatifloxacin ophthalmic solution) 0.5% may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs, discontinue use and institute alternative therapy.
  • Patients should be advised not to wear contact lenses if they have signs and symptoms of bacterial conjunctivitis or during the course of therapy with ZYMAXID.

What to do in case of emergency/overdose?[edit | edit source]

  • In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.

Can this medicine be used in pregnancy?[edit | edit source]

  • Because there are no adequate and well-controlled studies in pregnant women, ZYMAXID® solution should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Can this medicine be used in children?[edit | edit source]

  • The safety and effectiveness of ZYMAXID® in infants below one year of age have not been established.

What are the active and inactive ingredients in this medicine?[edit | edit source]

Active Ingredient:

  • gatifloxacin

Inactive Ingredients: edetate disodium water sodium chloride benzalkonium chloride hydrochloric acid sodium hydroxide

Who manufactures and distributes this medicine?[edit | edit source]

Manufactured by: Allergan, Inc. Irvine, CA 92612, U.S.A. ® marks owned by Allergan, Inc. Licensed from Kyorin Pharmaceuticals

Additional barcode labeling by: Physicians Total Care, Inc. Tulsa, Oklahoma

What should I know about storage and disposal of this medication?[edit | edit source]

  • Store at 15°-25°C (59°-77°F).
  • Protect from freezing.
Gatifloxacin Resources
Wikipedia

WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD