Amanitins
What are amaninitins?[edit | edit source]
Amaninitis are cyclic peptides extracted from carpophores of various mushroom species.
Use in molecular genetics[edit | edit source]
They are potent inhibitors of RNA polymerases in most eukaryotic species, blocking the production of mRNA and protein synthesis.
Study of transcription[edit | edit source]
These peptides are important in the study of transcription.
Types[edit | edit source]
There are 4 main types of amanitins, of which α-Amanitin is the most popular. α-Amanitin β-Amanitin γ-Amanitin ε-Amanitin
Mushroom poisoning[edit | edit source]
Alpha-amanitin is the main toxin from the species Amanitia phalloides, poisonous if ingested by humans or animals.
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Contributors: Prab R. Tumpati, MD