Erythromycin ethylsuccinate

Erythromycin Ethylsuccinate is a prodrug form of the macrolide antibiotic erythromycin. It is commonly used in the treatment of various bacterial infections, including those caused by Streptococcus, Staphylococcus, and Haemophilus species.

Pharmacology

Erythromycin Ethylsuccinate is converted in the body to erythromycin, which inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. This prevents the translocation of peptide chains, thereby inhibiting bacterial growth.

Clinical Use

Erythromycin Ethylsuccinate is used to treat a variety of bacterial infections, including respiratory tract infections, skin infections, and sexually transmitted infections. It is also used in patients who are allergic to penicillin.

Side Effects

Common side effects of Erythromycin Ethylsuccinate include nausea, vomiting, abdominal pain, and diarrhea. Rare but serious side effects include hepatotoxicity, QT prolongation, and allergic reactions.

Drug Interactions

Erythromycin Ethylsuccinate can interact with a number of other medications, including warfarin, theophylline, and certain antifungal drugs. It can also inhibit the metabolism of certain drugs, leading to increased drug levels and potential toxicity.

Dosage

The dosage of Erythromycin Ethylsuccinate varies depending on the type and severity of the infection, as well as the patient's age and overall health status.

See Also

• Erythromycin
• Macrolide
• Prodrug

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The following are macrolides

• Azithromycin
• Clarithromycin
• Erythromycin
• Fidaxomicin
• Telithromycin