Relugolix

What Is Relugolix ?

• Relugolix (Orgovyx) An orally available, non-peptide gonadotropin-releasing hormone (GnRH or luteinizing hormone-releasing hormone (LHRH)) antagonist, with potential antineoplastic activity.

What are the uses of this medicine?

• This medication is indicated for the treatment of adult patients with advanced prostate cancer.

How does this medicine work?

• Relugolix is a nonpeptide GnRH receptor antagonist that competitively binds to pituitary GnRH receptors
• This medicine reduces the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and consequently testosterone.
• Relugolix competitively binds to and blocks the GnRH receptor in the anterior pituitary gland, which both prevents GnRH binding to the GnRH receptor and inhibits the secretion and release of both luteinizing hormone (LH) and follicle stimulating hormone (FSH).
• In males, the inhibition of LH secretion prevents the release of testosterone from Leydig cells in the testes.
• Since testosterone is required to sustain prostate growth, reducing testosterone levels may inhibit hormone-dependent prostate cancer cell proliferation.

Who Should Not Use this medicine ?

• This medicine have no usage limitations

Is this medicine FDA approved?

• It was approved for use in the United States in 2020.

How should this medicine be used?

• Initiate treatment of this medicine with a loading dose of 360 mg on the first day and continue treatment with a 120 mg dose taken orally once daily at approximately the same time each day.
• This medicine can be taken with or without food
• Instruct patients to swallow tablets whole and not to crush or chew tablets.

What are the dosage forms and brand names of this medicine?

This medicine is available in fallowing doasage form:

• Available as 120 mg tablets

This medicine is available in fallowing brand namesː

• Orgovyx

What side effects can this medication cause?

Common possible side effects and laboratory abnormalities of this medicine include:

• hot flush
• glucose increased
• triglycerides increased
• musculoskeletal pain
• hemoglobin decreased
• alanine aminotransferase (ALT) increased
• fatigue
• aspartate aminotransferase (AST) increased
• constipation
• diarrhea

What special precautions should I follow?

• This medicine may prolong the QT interval.
• Orgovyx can cause fetal harm.
• Advise males with female partners of reproductive potential to use effective contraception.
• Orgovyx may cause infertility.

What to do in case of emergency/overdose?

• In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.

• Overdose related information is also available online at poisonhelp.org/help.
• In the event that the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services. In the United States, call 911.

Can this medicine be used in pregnancy?

• The safety and efficacy of Orgovyx have not been established in females.
• Orgovyx can cause fetal harm and loss of pregnancy when administered to a pregnant female.

Can this medicine be used in children?

• The safety and efficacy of Orgovyx in pediatric patients have not been established.

What should I know about storage and disposal of this medication?

• Store Orgovyx at room temperature.
• Do not store above 30°C (86°F).
• Dispense to patients in original container only.
• For bottles, keep container tightly closed after first opening.
• Keep out of reach of children.

• Dailymed label info on Relugolix
• FDA Relugolix

Relugolix Resources
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