Relugolix

From WikiMD's Wellness Encyclopedia

What Is Relugolix ?[edit | edit source]

Relugolix structure.png
Relugolix molecule ball.png


What are the uses of this medicine?[edit | edit source]

  • This medication is indicated for the treatment of adult patients with advanced prostate cancer.


How does this medicine work?[edit | edit source]

  • Relugolix is a nonpeptide GnRH receptor antagonist that competitively binds to pituitary GnRH receptors
  • This medicine reduces the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and consequently testosterone.
  • Relugolix competitively binds to and blocks the GnRH receptor in the anterior pituitary gland, which both prevents GnRH binding to the GnRH receptor and inhibits the secretion and release of both luteinizing hormone (LH) and follicle stimulating hormone (FSH).
  • In males, the inhibition of LH secretion prevents the release of testosterone from Leydig cells in the testes.
  • Since testosterone is required to sustain prostate growth, reducing testosterone levels may inhibit hormone-dependent prostate cancer cell proliferation.


Who Should Not Use this medicine ?[edit | edit source]

  • This medicine have no usage limitations


Is this medicine FDA approved?[edit | edit source]

  • It was approved for use in the United States in 2020.


How should this medicine be used?[edit | edit source]

  • Initiate treatment of this medicine with a loading dose of 360 mg on the first day and continue treatment with a 120 mg dose taken orally once daily at approximately the same time each day.
  • This medicine can be taken with or without food
  • Instruct patients to swallow tablets whole and not to crush or chew tablets.


What are the dosage forms and brand names of this medicine?[edit | edit source]

This medicine is available in fallowing doasage form:

  • Available as 120 mg tablets

This medicine is available in fallowing brand namesː

  • Orgovyx


What side effects can this medication cause?[edit | edit source]

Common possible side effects and laboratory abnormalities of this medicine include:


What special precautions should I follow?[edit | edit source]

  • This medicine may prolong the QT interval.
  • Orgovyx can cause fetal harm.
  • Advise males with female partners of reproductive potential to use effective contraception.
  • Orgovyx may cause infertility.


What to do in case of emergency/overdose?[edit | edit source]

  • In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.


Can this medicine be used in pregnancy?[edit | edit source]

  • The safety and efficacy of Orgovyx have not been established in females.
  • Orgovyx can cause fetal harm and loss of pregnancy when administered to a pregnant female.


Can this medicine be used in children?[edit | edit source]

  • The safety and efficacy of Orgovyx in pediatric patients have not been established.


What should I know about storage and disposal of this medication?[edit | edit source]

  • Store Orgovyx at room temperature.
  • Do not store above 30°C (86°F).
  • Dispense to patients in original container only.
  • For bottles, keep container tightly closed after first opening.
  • Keep out of reach of children.



Relugolix Resources

Contributors: Deepika vegiraju