Tobramycin Ophthalmic

What is Tobramycin Ophthalmic?

• Tobramycin Ophthalmic (AK-Tob; Tobrex) is a aminoglycoside topical ophthalmic antibiotic formulation used to treat eye infections.

Tobramycin

Tobramycin flat

What are the uses of this medicine?

• Tobramycin Ophthalmic (AK-Tob; Tobrex) is used in the treatment of external infections of the eye and its adnexa caused by susceptible bacteria.

How does this medicine work?

Tobramycin is an aminoglycoside antibacterial. Tobramycin is an aminoglycoside antibacterial produced by Streptomyces tenebrarius. It acts primarily by disrupting protein synthesis, leading to altered cell membrane permeability, progressive disruption of the cell envelope, and eventual cell death.

Who Should Not Use this medicine ?

This medicine cannot be used in patients:

• with known hypersensitivity to any of its components.

What drug interactions can this medicine cause?

• Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.

Be sure to mention any of the following:

• other eye medications

Is this medicine FDA approved?

• It was patented in 1965, and approved for medical use in 1974.

How should this medicine be used?

Recommended dosage:

• In mild to moderate disease, instill 1 or 2 drops into the affected eye(s) every 4 hours.
• In severe infections, instill 2 drops into the eye(s) hourly until improvement, following which treatment should be reduced prior to discontinuation.

Administration:

• Ophthalmic tobramycin comes as as a solution (liquid) to instill in the eyes and as an eye ointment to apply to the eyes.
• The eye drops are usually applied every 4 to 8 hours and the ointment is usually applied two to four times a day.

What are the dosage forms and brand names of this medicine?

This medicine is available in fallowing doasage form:

• As Tobramycin Ophthalmic Solution USP, 0.3%

This medicine is available in fallowing brand namesː

• AK-Tob; Tobrex

What side effects can this medication cause?

The most common side effects of this medicine include:

• hypersensitivity
• localized ocular toxicity, including lid itching and swelling
• conjunctival erythema

Additional adverse reactions may include:

• anaphylactic reaction
• Stevens-Johnson syndrome
• erythema multiforme

What special precautions should I follow?

• Severity of hypersensitivity reactions may vary from local effects to generalized reactions such as erythema, itching, urticaria, skin rash, anaphylaxis, anaphylactoid reactions, or bullous reactions. If a sensitivity reaction to tobramycin ophthalmic solution, 0.3% occurs, discontinue use.
• Prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs, appropriate therapy should be initiated.
• Patients should be advised not to wear contact lenses if they have signs and symptoms of bacterial ocular infection.
• Do not touch dropper tip to any surface, as this may contaminate the solution.
• Avoid rubbing your eyes even if your vision is blurred. Do not drive a car or operate machinery if you are unable to see clearly.
• Because of the potential for adverse reactions in nursing infants from tobramycin ophthalmic solution, a decision should be made whether to discontinue nursing the infant or discontinue the drug, taking into account the importance of the drug to the mother.

What to do in case of emergency/overdose?

• In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.

• Overdose related information is also available online at poisonhelp.org/help.
• In the event that the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services. In the United States, call 911.

Can this medicine be used in pregnancy?

• There are, however, no adequate and well-controlled studies in pregnant women.
• Because animal studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

Can this medicine be used in children?

• Safety and effectiveness in pediatric patients below the age of 2 months has not been established.

What are the active and inactive ingredients in this medicine?

Active:

• tobramycin 3 mg (0.3%).

Inactives:

• boric acid, sodium sulfate, sodium chloride, tyloxapol and purified water. Sodium hydroxide and/or sulfuric acid (to adjust pH).

Tobramycin ophthalmic solution, 0.3% has a pH range between 7.0 and 8.0.

Preservative Added:

• benzalkonium chloride 0.1 mg (0.01%).

Who manufactures and distributes this medicine?

Distributed by:

• Bausch + Lomb, a division of Bausch Health US, LLC
• Bridgewater, NJ USA

Manufactured by:

• Bausch & Lomb Incorporated
• Tampa, FL USA

What should I know about storage and disposal of this medication?

• Store at 2° to 25°C (36° to 77°F).
• Avoid excessive heat.
• After opening, Tobramycin Ophthalmic Solution USP, 0.3% can be used until the expiration date on the bottle.

• Dailymed label info on Tobramycin Ophthalmic
• FDA Tobramycin Ophthalmic

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