G-15 (drug)
G-15 (drug)[edit | edit source]
G-15 is a synthetic compound that acts as a selective antagonist of the G protein-coupled estrogen receptor (GPER), also known as GPR30. It is primarily used in research settings to study the physiological and pathological roles of GPER in various tissues.
Chemical Structure and Properties[edit | edit source]
G-15 is a non-steroidal compound with a complex chemical structure that allows it to selectively bind to GPER without significant interaction with classical estrogen receptors, such as ERα and ERβ. This selectivity is crucial for its use in research, as it enables scientists to isolate the effects mediated by GPER.
Mechanism of Action[edit | edit source]
G-15 functions by competitively inhibiting the binding of endogenous estrogens to GPER. By blocking this receptor, G-15 can modulate various signaling pathways that are activated by GPER, including those involved in cell proliferation, apoptosis, and migration. This makes it a valuable tool for studying estrogen-related signaling in non-genomic pathways.
Research Applications[edit | edit source]
G-15 is widely used in preclinical studies to explore the role of GPER in different physiological processes and diseases. Some of the key areas of research include:
- Cardiovascular System: Investigating the protective effects of GPER activation in cardiovascular diseases.
- Cancer: Understanding the role of GPER in the progression of hormone-dependent cancers, such as breast and ovarian cancer.
- Metabolic Disorders: Studying the impact of GPER on glucose metabolism and obesity.
Pharmacokinetics[edit | edit source]
The pharmacokinetic profile of G-15 is not extensively documented, as it is primarily used in vitro and in animal models. However, its solubility, stability, and bioavailability are important considerations for experimental design.
Safety and Toxicity[edit | edit source]
As G-15 is mainly used in laboratory research, comprehensive safety and toxicity data in humans are not available. Researchers handling G-15 should follow standard laboratory safety protocols to minimize exposure and potential risks.
Also see[edit | edit source]
- G protein-coupled estrogen receptor
- Estrogen receptor
- Selective estrogen receptor modulator
- Non-genomic actions of estrogen
Template:Receptor pharmacology
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD