Enolicam
Enolicam is a non-steroidal anti-inflammatory drug (NSAID) that is used primarily for its analgesic and anti-inflammatory properties. It belongs to the class of oxicams, which are known for their long half-lives and ability to provide sustained relief from pain and inflammation.
Pharmacology[edit | edit source]
Enolicam works by inhibiting the enzyme cyclooxygenase (COX), which is responsible for the conversion of arachidonic acid to prostaglandins. Prostaglandins are mediators of inflammation and pain, and by reducing their synthesis, Enolicam effectively reduces symptoms associated with inflammatory conditions.
Mechanism of Action[edit | edit source]
Enolicam selectively inhibits the COX-2 isoform of the enzyme, which is primarily involved in the inflammatory response. This selectivity helps to minimize gastrointestinal side effects that are commonly associated with non-selective COX inhibitors.
Pharmacokinetics[edit | edit source]
Enolicam is well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 2 to 4 hours after oral administration. It is highly protein-bound and has a long elimination half-life, allowing for once-daily dosing in most cases. The drug is metabolized in the liver and excreted primarily in the urine.
Clinical Uses[edit | edit source]
Enolicam is indicated for the treatment of various inflammatory conditions, including:
- Rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
- Acute musculoskeletal pain
Adverse Effects[edit | edit source]
Common side effects of Enolicam include gastrointestinal disturbances such as nausea, dyspepsia, and diarrhea. Due to its COX-2 selectivity, it has a lower risk of causing gastric ulcers compared to non-selective NSAIDs. However, it may still pose a risk of cardiovascular events, similar to other COX-2 inhibitors.
Contraindications[edit | edit source]
Enolicam should not be used in patients with known hypersensitivity to the drug or other oxicams. It is also contraindicated in patients with active peptic ulcer disease, severe renal impairment, or significant hepatic dysfunction.
Interactions[edit | edit source]
Enolicam may interact with other medications, including:
- Anticoagulants: Increased risk of bleeding
- Antihypertensives: Reduced efficacy
- Diuretics: Reduced diuretic effect
Also see[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
