Cinmetacin
| Cinmetacin.svg | |
Cinmetacin is a non-steroidal anti-inflammatory drug (NSAID) used primarily for its analgesic and anti-inflammatory properties. It is a derivative of indomethacin, a well-known NSAID, and is used in the treatment of various inflammatory conditions such as arthritis and musculoskeletal pain.
Pharmacology[edit | edit source]
Cinmetacin works by inhibiting the enzyme cyclooxygenase (COX), which is responsible for the conversion of arachidonic acid to prostaglandins. Prostaglandins are mediators of inflammation and pain, and by reducing their synthesis, cinmetacin alleviates symptoms associated with inflammation.
Mechanism of Action[edit | edit source]
Cinmetacin is a non-selective COX inhibitor, meaning it inhibits both COX-1 and COX-2 enzymes. COX-1 is involved in the protection of the gastric mucosa and platelet aggregation, while COX-2 is primarily involved in the inflammatory response. The inhibition of COX-2 leads to the desired anti-inflammatory effects, but the inhibition of COX-1 can result in gastrointestinal side effects.
Pharmacokinetics[edit | edit source]
Cinmetacin is absorbed from the gastrointestinal tract and undergoes hepatic metabolism. It is excreted primarily in the urine. The drug has a half-life that allows for dosing multiple times a day, depending on the formulation and the condition being treated.
Clinical Uses[edit | edit source]
Cinmetacin is used in the management of:
- Rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
- Acute musculoskeletal disorders
Side Effects[edit | edit source]
Common side effects of cinmetacin include:
- Gastrointestinal disturbances such as nausea, vomiting, and dyspepsia
- Headache
- Dizziness
- Rash
Serious side effects may include:
- Gastrointestinal bleeding
- Peptic ulcers
- Renal impairment
Contraindications[edit | edit source]
Cinmetacin should not be used in individuals with:
- Known hypersensitivity to cinmetacin or other NSAIDs
- Active gastrointestinal bleeding or ulceration
- Severe renal or hepatic impairment
Interactions[edit | edit source]
Cinmetacin may interact with other medications, including:
- Anticoagulants such as warfarin, increasing the risk of bleeding
- Other NSAIDs, which may increase the risk of adverse effects
- Diuretics, potentially reducing their effectiveness
Also see[edit | edit source]
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Contributors: Prab R. Tumpati, MD
