Diffuse cutaneous systemic sclerosis
Other Names: Diffuse cutaneous systemic sclerosis; DcSSc; Progressive cutaneous systemic scleroderma; Progressive cutaneous systemic sclerosis; Diffuse cutaneous systemic scleroderma
A variant of systemic scleroderma characterized by sclerosis of the skin, raynaud phenomenon, and organ involvement, including pulmonary fibrosis, renal disease, and gastrointestinal tract involvement.
Diffuse cutaneous systemic sclerosis (dcSSc) is a subtype of systemic scleroderma (systemic sclerosis) characterized by skin hardening (fibrosis) and problems in many organs of the body. The disease can occur at any age but mainly affects people between 40 and 50 years of age.
Cause[edit | edit source]
The exact cause of the condition is unknown.
Signs and symptoms[edit | edit source]
Symptoms include Raynaud’s phenomenon; skin fibrosis beginning on the fingers and face that rapidly becomes generalized; "spider veins" (telangiectasias) on the thorax, face, lips, tongue, and fingers; gastroesophageal reflux; and difficulty eating (dysphagia) along with weight loss, vomiting, diarrhea or constipation. Dry mouth and dental involvement can occur. Joint pain (arthralgias), muscular pain, weakness, cramps, and destruction of the tips of the fingers or toes (acroosteolysis) are frequent. Severe problems involving the lung (fibrosis or pulmonary hypertension) and kidney problems may also occur.
For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. 80%-99% of people have these symptoms
- Autoimmunity(Autoimmune disease)
- Dyspnea(Trouble breathing)
- Gastroesophageal reflux(Acid reflux)
- Narrow foramen obturatorium
- Oliguria
- Pulmonary infiltrates(Lung infiltrates)
30%-79% of people have these symptoms
- Arthralgia(Joint pain)
- Arthritis(Joint inflammation)
- Carious teeth(Dental cavities)
- Dyspareunia
- Dysphagia(Poor swallowing)
- Flexion contracture(Flexed joint that cannot be straightened)
- Malabsorption(Intestinal malabsorption)
- Muscle weakness(Muscular weakness)
- Osteolysis(Breakdown of bone)
- Pulmonary fibrosis
- Skin ulcer(Open skin sore)
- Telangiectasia of the skin
- Xerostomia(Dry mouth)
5%-29% of people have these symptoms
- Abnormal bowel sounds
- Congestive heart failure(Cardiac failure)
- Hypertensive crisis
- Nausea and vomiting
- Pulmonary arterial hypertension(Increased blood pressure in blood vessels of lungs)
- Renal insufficiency(Renal failure)
Diagnosis[edit | edit source]
Treatment[edit | edit source]
There is currently no cure. Treatment depends of the symptoms, but may include medication and surgery.
NIH genetic and rare disease info[edit source]
Diffuse cutaneous systemic sclerosis is a rare disease.
| Diffuse cutaneous systemic sclerosis Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Deepika vegiraju
