CB-25

BzATP_structure.png Chemical structure of BzATP

BzATP (2'(3')-O-(4-benzoylbenzoyl)adenosine 5'-triphosphate) is a potent agonist of the P2X receptor family, particularly the P2X7 receptor. It is widely used in pharmacology and neuroscience research to study the function of P2X receptors, which are a type of ligand-gated ion channel activated by adenosine triphosphate (ATP).

Chemical Properties

BzATP is a modified form of ATP, where a benzoylbenzoyl group is attached to the ribose moiety of ATP. This modification enhances its selectivity and potency for P2X receptors, especially P2X7, compared to ATP itself. The chemical formula of BzATP is C₁₀H₁₆N₅O₁₃P₃, and it has a molar mass of 551.18 g/mol.

Mechanism of Action

BzATP acts as an agonist at P2X receptors, which are trimeric ion channels that open in response to binding extracellular ATP. The P2X7 receptor, in particular, is known for its role in inflammation and cell death. Upon activation by BzATP, the P2X7 receptor allows the influx of calcium and sodium ions and the efflux of potassium ions, leading to various downstream effects such as the activation of caspases and the release of pro-inflammatory cytokines.

Applications in Research

BzATP is extensively used in research to:

• Investigate the physiological and pathological roles of P2X receptors.
• Study the mechanisms of neuroinflammation and neurodegeneration.
• Explore the potential therapeutic targets for diseases involving P2X7 receptor activation, such as chronic pain, cancer, and autoimmune disorders.

Safety and Handling

As with many research chemicals, BzATP should be handled with care. It is important to follow appropriate safety protocols, including the use of personal protective equipment (PPE) and working in a well-ventilated area or fume hood.

Also see

• P2X receptor
• Adenosine triphosphate
• Ion channel
• Neuroinflammation