Cefiderocol sulfate tosylate

Cefiderocol sulfate tosylate is an antibiotic drug used in the treatment of various bacterial infections. It is a siderophore cephalosporin that has a unique mechanism of action, allowing it to overcome bacterial resistance mechanisms.

Mechanism of Action

Cefiderocol sulfate tosylate works by binding to iron, which is essential for bacterial growth. It then uses the bacteria's own iron transport system to enter the bacterial cell, where it inhibits the synthesis of the bacterial cell wall, leading to cell death.

Clinical Use

Cefiderocol sulfate tosylate is used to treat a variety of bacterial infections, including those caused by Gram-negative bacteria such as Pseudomonas aeruginosa and Escherichia coli. It is particularly useful in treating infections caused by bacteria that are resistant to other antibiotics.

Side Effects

Like all antibiotics, cefiderocol sulfate tosylate can cause side effects. These may include nausea, vomiting, diarrhea, and allergic reactions. In rare cases, it can cause more serious side effects such as kidney damage or Clostridium difficile infection.

Development and Approval

Cefiderocol sulfate tosylate was developed by Shionogi Inc., a Japanese pharmaceutical company. It was approved by the Food and Drug Administration (FDA) in the United States in 2019 for the treatment of complicated urinary tract infections and infections caused by susceptible Gram-negative microorganisms in patients with limited or no alternative treatment options.

See Also

• Antibiotics
• Bacterial resistance
• Siderophore
• Cephalosporin