Glucokinase regulator
Glucagon-like peptide (GLP) is a term that refers to two incretin hormones, namely GLP-1 and GLP-2, which are produced in the intestine and released in response to food intake. These peptides play a crucial role in regulating blood glucose levels and intestinal growth, respectively.
GLP-1[edit | edit source]
GLP-1 (Glucagon-like peptide-1) is a potent hormone that induces insulin secretion. It is released from L cells in the intestine in response to food intake. GLP-1 has several functions, including enhancing glucose-dependent insulin secretion, suppressing glucagon secretion, slowing gastric emptying, and reducing food intake. These actions collectively help to regulate postprandial glucose levels.
GLP-2[edit | edit source]
GLP-2 (Glucagon-like peptide-2) is also released from L cells in the intestine, but its primary role is to regulate intestinal growth and absorption. GLP-2 stimulates the growth of the intestinal lining, enhances nutrient absorption, and reduces intestinal permeability. It is being investigated for its potential use in treating intestinal diseases such as short bowel syndrome and inflammatory bowel disease.
Clinical significance[edit | edit source]
GLP-1 and GLP-2 have significant clinical implications, particularly in the management of diabetes and intestinal diseases. GLP-1 receptor agonists and DPP-4 inhibitors, which increase the levels or action of GLP-1, are widely used in the treatment of type 2 diabetes. On the other hand, synthetic GLP-2 is used to treat short bowel syndrome and is being investigated for other intestinal diseases.
See also[edit | edit source]
 | This gastroenterology article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
