Amoxicillin-Clavulanate

Information about Amoxicillin-Clavulanate[edit source]

The combination of amoxicillin and clavulanate is an oral antibiotic widely used in the treatment of mild-to-moderate bacterial infections including sinusitis, bronchitis, otitis media, cellulitis and community acquired pneumonia.

Amoxicillin clavulanic acid

Liver toxicity[edit | edit source]

Amoxicillin-clavulanate is currently the most common cause of clinically apparent, drug induced acute liver injury both in the United States and Europe.

Amoxicillin clavulanic acid ball-and-stick

Mechanism of action of Amoxicillin-Clavulanate[edit source]

The combination of amoxicillin and clavulanate is a commonly used antibiotic which is active against many bacterial organisms that cause sinusitis, bronchitis, otitis media, skin and tissue infections and community acquired pneumonia.

The combination consists of amoxicillin which is a semisynthetic, third generation penicillin and clavulanate which is a beta lactam that acts as an inhibitor of beta lactamase, the major bacterial enzyme responsible for penicillin resistance.

FDA approval[edit | edit source]

Amoxicillin-clavulanate was approved for use in the United States in 1984 and, currently, 2 to 5 million prescriptions are filled yearly, making it one of the most common antibiotic regimens used.

Clinical use of Amoxicillin-Clavulanate[edit source]

Allergic exanthema amoxicillin

Current indications are for mild-to-moderate bacterial infections due to known or suspected penicillinase resistant gram positive or gram negative organisms.

Dose[edit | edit source]

This combination is provided in multiple dose combinations, typically as 250 to 875 mg amoxicillin with 125 mg of clavulanate, given two to three times daily for 7 to 10 days. Amoxicillin-clavulanate is available in multiple generic formulations and under the brand name Augmentin.

Side effects of Amoxicillin-Clavulanate[edit source]

Common side effects include gastrointestinal upset, diarrhea and rash.

Amoxicillin-Clavulanate Resources
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