Quercetin 3-O-sulfate

Quercetin 3-O-sulfate

Quercetin 3-O-sulfate is a sulfate ester of the flavonol quercetin. It is one of the many metabolites of quercetin, and is formed in the body after the ingestion of foods rich in quercetin, such as onions, apples, and berries.

Chemistry

Quercetin 3-O-sulfate is a sulfate ester, which means it is formed by the combination of a sulfuric acid molecule and a quercetin molecule. The "3-O" in its name refers to the position of the sulfate group on the quercetin molecule. Like all flavonols, quercetin has a three-ring structure, with the sulfate group attached to the third carbon atom in the second ring.

Biosynthesis

The biosynthesis of quercetin 3-O-sulfate occurs in the liver, where quercetin is metabolized by the enzyme sulfotransferase. This enzyme transfers a sulfate group from a donor molecule, such as 3'-phosphoadenosine 5'-phosphosulfate (PAPS), to the 3-O position on the quercetin molecule.

Biological Activity

Quercetin 3-O-sulfate has been found to have several biological activities. It has antioxidant properties, meaning it can neutralize harmful free radicals in the body. It also has anti-inflammatory effects, and can inhibit the production of pro-inflammatory cytokines. In addition, it has been found to have antiviral activity against several types of viruses.

Health Implications

Due to its biological activities, quercetin 3-O-sulfate has potential health benefits. Its antioxidant and anti-inflammatory effects may help protect against chronic diseases such as heart disease and cancer. Its antiviral activity suggests it could be used as a natural antiviral agent. However, more research is needed to fully understand its health implications and potential uses in medicine.

See Also

• Quercetin
• Flavonols
• Sulfate esters