Testosterone palmitate

Testosterone Palmitate is an ester of testosterone, a naturally occurring androgen. It is a long-acting prodrug of testosterone that is less polar than free testosterone. Testosterone palmitate is used in androgen replacement therapy. It is given by intramuscular injection and has a longer duration of action than unmodified testosterone.

Chemistry[edit | edit source]

Testosterone palmitate, also known as testosterone hexadecanoate, is a synthetic androstane steroid and a derivative of testosterone. It is an androgen ester—specifically, the C17β palmitate (hexadecanoate) ester of testosterone. Other important testosterone esters include testosterone cypionate, testosterone enanthate, testosterone propionate, and testosterone undecanoate.

Pharmacology[edit | edit source]

As a prodrug of testosterone, testosterone palmitate is considered to be a natural and bioidentical form of testosterone. Once in the body, it is metabolized to yield free testosterone. Compared to unmodified testosterone, the prodrug has improved pharmacokinetics, notably a longer half-life and duration of action when given by intramuscular injection.

Medical Use[edit | edit source]

Testosterone palmitate is used in androgen replacement therapy, primarily in the treatment of male hypogonadism. It is given by intramuscular injection once every one to two weeks. The medication has a longer duration of action than unmodified testosterone and allows for less frequent administration.

Side Effects[edit | edit source]

Potential side effects of testosterone palmitate include androgenic effects such as acne, hirsutism, and voice deepening, as well as estrogenic effects like gynecomastia and fluid retention. In addition, the medication can have adverse effects on lipid profiles and may increase the risk of cardiovascular disease.