Androstanolone valerate

Androstanolone Valerate is a synthetic androgen and anabolic steroid (AAS) medication which is used in the treatment of male hypogonadism. It is an ester of androstanolone (dihydrotestosterone, DHT), specifically the valerate ester, and acts as a prodrug of androstanolone in the body. Androstanolone valerate is administered via intramuscular injection.

Medical Uses

Androstanolone valerate is primarily used in the medical field for the treatment of male hypogonadism, a condition where the body does not produce enough testosterone. Testosterone is essential for the development and maintenance of male sex characteristics and normal reproductive function. By supplementing the body's natural testosterone levels, androstanolone valerate can help alleviate the symptoms associated with hypogonadism, such as decreased libido, erectile dysfunction, and reduced muscle mass.

Pharmacology

Mechanism of Action

As a derivative of DHT, androstanolone valerate exerts its effects by binding to and activating the androgen receptor (AR). This leads to a series of intracellular events that promote the expression of specific genes involved in male sexual development and secondary sex characteristics. Unlike testosterone, DHT cannot be aromatized to estrogen, which means androstanolone valerate does not have the risk of estrogenic side effects such as gynecomastia.

Pharmacokinetics

Upon intramuscular injection, androstanolone valerate is slowly absorbed into the bloodstream and then hydrolyzed into androstanolone. Androstanolone has a high affinity for the androgen receptor and is metabolized in the liver. The metabolites are then excreted through the urine.

Adverse Effects

The use of androstanolone valerate can lead to several side effects, similar to those associated with other AAS. These may include acne, hair loss, voice changes, and increased body hair. Due to its androgenic nature, androstanolone valerate can also exacerbate benign prostatic hyperplasia (BPH) and may increase the risk of prostate cancer in predisposed individuals. It is important for patients to be monitored regularly while on treatment.

Contraindications

Androstanolone valerate is contraindicated in individuals with known hypersensitivity to the drug, prostate cancer, and male breast cancer. It should also be used with caution in patients with a history of cardiovascular disease, liver disease, and in elderly patients.

See Also

• Testosterone
• Anabolic steroid
• Hypogonadism
• Androgen receptor