3α-androstanediol
A metabolite of dihydrotestosterone
3α-Androstanediol (also known as 5α-androstane-3α,17β-diol) is a steroid metabolite of dihydrotestosterone (DHT). It is an important compound in the study of androgen metabolism and function.
Structure and Properties[edit | edit source]
3α-Androstanediol is a C19H32O2 steroid with a molecular weight of 292.46 g/mol. It is characterized by the presence of hydroxyl groups at the 3α and 17β positions on the androstane backbone.
Biosynthesis[edit | edit source]
3α-Androstanediol is synthesized from dihydrotestosterone (DHT) through the action of the enzyme 3α-hydroxysteroid dehydrogenase. This conversion is part of the metabolic pathway that regulates the levels of active androgens in the body.
Biological Role[edit | edit source]
3α-Androstanediol is considered a weak androgen, but it plays a significant role in modulating the effects of more potent androgens like DHT. It is involved in the regulation of androgen receptor activity and can influence various physiological processes, including sexual differentiation, hair growth, and sebaceous gland activity.
Clinical Significance[edit | edit source]
The levels of 3α-androstanediol can be indicative of certain medical conditions. For example, elevated levels may be associated with androgen insensitivity syndrome or other disorders of androgen metabolism. It is also studied in the context of prostate cancer and other androgen-related diseases.
Research and Applications[edit | edit source]
Research into 3α-androstanediol has implications for understanding hormone replacement therapy, endocrine disorders, and the development of androgen receptor antagonists. It is also used as a marker in studies of steroidogenesis and androgen metabolism.
Also see[edit | edit source]
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